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E3 Ubiquitin-Protein Ligase SMURF2 (SMURF2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS951177

MBS951177 is a recombinant protein targeting Smurf2. Also known as Recombinant Mouse E3 ubiquitin-protein ligase SMURF2 (Smurf2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1610 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase SMURF2 (Smurf2), Recombinant Protein
Full Product Name
Recombinant Mouse E3 ubiquitin-protein ligase SMURF2 (Smurf2)
Product Gene Name
Smurf2 recombinant protein
Sequence
MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL GPNDNDTVRG QIVVSLQSRD RIGTGGQVVD CSRLFDNDLP DGWEERRTAS GRIQYLNHIT RTTQWERPTR PASEYSSPGR PLSCFVDENT PITGTNGATC GHSSDPRLAE RRVRSQRHRN YMSRTHLHTP PDLPEGYEQR TTQQGQVYFL HTQTGVSTWH DPRVPRDLSN INCEELGPLP PGWEIRNTAT GRVYFVDHNN RTTQFTDPRL SANLHLVLNR QNQLKDQQQQ QVVPLCPDDT ECLTVPRYKR DLVQKLKILR QELSQQQPQA GHCRIEVSRE EIFEESYRQV MKMRPKDLWK RLMIKFRGEE GLDYGGVARE WLYLLSHEML NPYYGLFQYS RDDIYTLQIN PDSAVNPEHL SYFHFVGRIM GMAVFHGHYI DGGFTLPFYK QLLGKSITLD DMELVDPDLH NSLVWILEND ITGVLDHTFC VEHNAYGEII QHELKPNGKS IPVTEENKKE YVRLYVNWRF LRGIEAQFLA LQKGFNEVIP QHLLKTFDEK ELELIICGLG KIDVSDWKVN TRLKHCTPDS NVVKWFWKAV EFFDEERRAR LLQFVTGSSR VPLQGFKALQ GAAGPRLFTI HQIDACTNNL PKAHTCFNRI DIPPYESYEK LYEKLLTAIE ETCGFAVE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
84,569 Da
Sequence Positions
1-748, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for A2A5Z6
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Smurf2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Smurf2. It may not necessarily be applicable to this product.

NCBI GI #
254939680
NCBI GeneID
66313
NCBI Accession #
NP_079757.2
UniProt Primary Accession #
A2A5Z6
UniProt Secondary Accession #
Q5IRE6; A2A5Z7
UniProt Related Accession #
A2A5Z6
GenBank Nucleotide #
NM_025481.2
NCBI Official Full Name
E3 ubiquitin-protein ligase SMURF2
NCBI Official Synonym Full Names
SMAD specific E3 ubiquitin protein ligase 2
NCBI Official Symbol
Smurf2
NCBI Official Synonym Symbols
AI558114; AI649275; 2810411E22Rik
UniProt Protein Name
E3 ubiquitin-protein ligase SMURF2
UniProt Synonym Protein Names
HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
Smurf2
NCBI Protein Information
E3 ubiquitin-protein ligase SMURF2

UniProt Comments for Smurf2

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
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Research Articles on Smurf2

1. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Smurf2 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Asymmetric Localization Of PCP Proteins Pathway antibodies  Asymmetric Localization Of PCP Proteins Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram

Diseases associated with Smurf2 recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >20 publications with Smurf2 and Fibrosis
 Kidney Diseases Antibodies  >14 publications with Smurf2 and Kidney Diseases
 Breast Neoplasms Antibodies  >12 publications with Smurf2 and Breast Neoplasms
 Disease Models, Animal Antibodies  >11 publications with Smurf2 and Disease Models, Animal
 Skin Diseases Antibodies  >9 publications with Smurf2 and Skin Diseases
 Necrosis Antibodies  >9 publications with Smurf2 and Necrosis
 Inflammation Antibodies  >7 publications with Smurf2 and Inflammation
 Nervous System Diseases Antibodies  >5 publications with Smurf2 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with Smurf2 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >3 publications with Smurf2 and Liver Diseases

Organs/Tissues associated with Smurf2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >22 publications with Smurf2 and Bone
 Kidney Antibodies  >13 publications with Smurf2 and Kidney
 Other Antibodies  >13 publications with Smurf2 and Other
 Lung Antibodies  >7 publications with Smurf2 and Lung
 Blood Antibodies  >5 publications with Smurf2 and Blood
 Embryonic Tissue Antibodies  >5 publications with Smurf2 and Embryonic Tissue
 Liver Antibodies  >4 publications with Smurf2 and Liver
 Brain Antibodies  >4 publications with Smurf2 and Brain
 Prostate Antibodies  >3 publications with Smurf2 and Prostate
 Skin Antibodies  >2 publications with Smurf2 and Skin
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