Human TMPRSS15 Recombinant Protein – Cat# MBS951180

Enteropeptidase (TMPRSS15), Partial (TMPRSS15) Human Recombinant Protein

Name: TMPRSS15 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS951180
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS951180

MBS951180 is a recombinant protein targeting TMPRSS15. Also known as Recombinant Human Enteropeptidase (TMPRSS15), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Enteropeptidase (TMPRSS15), partial, Recombinant Protein

Full Product Name

Recombinant Human Enteropeptidase (TMPRSS15), partial

Product Gene Name

TMPRSS15 recombinant protein

Product Synonym Gene Name

TMPRSS15; ENTK; PRSS7

Product Synonym Names

Enteropeptidase; EC=3.4.21.9; Enterokinase; Serine protease 7; Transmembrane protease serine 15Cleaved into the following 2 chains:; 1. Enteropeptidase non-catalytic heavy chain; 2. Enteropeptidase catalytic light chain

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

112,935 Da

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

606635

3D Structure

ModBase 3D Structure for P98073

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TMPRSS15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TMPRSS15. It may not necessarily be applicable to this product.

NCBI GI #

223942069

NCBI GeneID

5651

NCBI Accession #

NP_002763.2

UniProt Primary Accession #

P98073

UniProt Secondary Accession #

Q2NKL7

UniProt Related Accession #

P98073

GenBank Nucleotide #

NM_002772.2

NCBI Official Full Name

enteropeptidase

NCBI Official Synonym Full Names

transmembrane protease, serine 15

NCBI Official Symbol

TMPRSS15

NCBI Official Synonym Symbols

ENTK; PRSS7

UniProt Protein Name

Enteropeptidase

UniProt Synonym Protein Names

Enterokinase; Serine protease 7; Transmembrane protease serine 15Cleaved into the following 2 chains:Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain

Protein Family

Enteropeptidase

UniProt Gene Name

TMPRSS15

UniProt Synonym Gene Names

ENTK; PRSS7

UniProt Entry Name

ENTK_HUMAN

NCBI Protein Information

enteropeptidase; serine protease 7; enterokinase catalytic subunit; protease, serine, 7 (enterokinase)

NCBI Summary for TMPRSS15

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

UniProt Comments for TMPRSS15

PRSS7: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family.

Protein type: Protease; Membrane protein, integral; EC 3.4.21.9

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: integral to membrane; brush border

Molecular Function: serine-type endopeptidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; proteolysis

Disease: Enterokinase Deficiency

Research Articles on TMPRSS15

1. The Y174R variant showed improved specificities for substrates containing the sequences DDDDK (kcat/KM = 6.83 x 106 M-1 sec-1) and DDDDR (kcat/KM = 1.89 x 107 M-1 sec-1) relative to all other enteropeptidase variants reported to date.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.