Human MAGEA2 Recombinant Protein – Cat# MBS951470

Melanoma-Associated Antigen 2 (MAGEA2) Human Recombinant Protein

Name: MAGEA2 Recombinant Protein; Melanoma-Associated Antigen 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS951470
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS951470

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Melanoma-associated antigen 2 (MAGEA2), Recombinant Protein

Full Product Name

Recombinant Human Melanoma-associated antigen 2 (MAGEA2)

Product Gene Name

MAGEA2 recombinant protein

Sequence

MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL GEVPAADSPS PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD LESEFQAAIS RKMVELVHFL LLKYRAREPV TKAEMLESVL RNCQDFFPVI FSKASEYLQL VFGIEVVEVV PISHLYILVT CLGLSYDGLL GDNQVMPKTG LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA HPRKLLMQDL VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS YPPLHERALR EGEE

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

35,055 Da

Sequence Positions

1-314aa; Full Length Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

300173

3D Structure

ModBase 3D Structure for P43356

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MAGEA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAGEA2 purchase

MBS951470 is a recombinant protein targeting MAGEA2. Also known as Recombinant Human Melanoma-associated antigen 2 (MAGEA2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGEA2. It may not necessarily be applicable to this product.

NCBI GI #

542133120

NCBI GeneID

4101

NCBI Accession #

NP_001269430.1

UniProt Primary Accession #

P43356

UniProt Secondary Accession #

Q32NC6; A8K328

UniProt Related Accession #

P43356

GenBank Nucleotide #

NM_001282501.1

NCBI Official Full Name

melanoma-associated antigen 2

NCBI Official Synonym Full Names

MAGE family member A2

NCBI Official Symbol

MAGEA2

NCBI Official Synonym Symbols

CT1.2; MAGE2; MAGEA2A

UniProt Protein Name

Melanoma-associated antigen 2

UniProt Synonym Protein Names

Cancer/testis antigen 1.2; CT1.2; MAGE-2 antigen

Protein Family

Melanoma-associated antigen

UniProt Gene Name

MAGEA2

UniProt Synonym Gene Names

MAGE2; MAGEA2A; CT1.2

NCBI Protein Information

melanoma-associated antigen 2

UniProt Comments for MAGEA2

Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Research Articles on MAGEA2

1. suppression of MAGEA2 in lung cancer cells significantly reduced the growth/survival of cancer cells. High-MAGEA2 was identified as an independent prognostic factor in lung adenocarcinoma. Specific inhibition of MAGEA2 may be a promising therapeutic strategy for patients with lung cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MAGEA2 recombinant protein

Reference Product	PubMed Publications
PML recombinant protein	>1 publications with MAGEA2 and PML
HDAC3 recombinant protein	>1 publications with MAGEA2 and HDAC3

Diseases associated with MAGEA2 recombinant protein

Disease Name	Pubmed Publications
Carcinoma, Small Cell Antibodies	>1 publications with MAGEA2 and Carcinoma, Small Cell
Neuroectodermal Tumors Antibodies	>1 publications with MAGEA2 and Neuroectodermal Tumors
Lung Neoplasms Antibodies	>1 publications with MAGEA2 and Lung Neoplasms
Carcinoma, Squamous Cell Antibodies	>1 publications with MAGEA2 and Carcinoma, Squamous Cell
Leukemia Antibodies	>1 publications with MAGEA2 and Leukemia
Carcinoma Antibodies	>1 publications with MAGEA2 and Carcinoma
Multiple Myeloma Antibodies	>1 publications with MAGEA2 and Multiple Myeloma

Organs/Tissues associated with MAGEA2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>4 publications with MAGEA2 and Testis