Transcription Factor 15 (TCF15) Chicken Recombinant Protein

Function: May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

Subunit structure: Efficient DNA binding requires dimerization with another bHLH protein

By similarity.

Subcellular location: Nucleus

By similarity.

Developmental stage: First detected in a subpopulation of cells lateral to the primitive streak corresponding with the area of prospective segmental plate mesoderm and somites. Later in development, it is expressed throughout the segmental plate and newly formed somites and is restricted to the paraxial mesoderm. After somite formation, its expression decline in the lateral region of the somite. Later it is expressed at highest levels at the cranial and caudal edges of the more mature somites. As the dermomyotome and sclerotome formed, expression disappeared from the ventral regions of the somite, but persisted in the dermomyotome. When the dermomyotome developed further into the dermatome and myotome, expression is detected in both compartments, although more prominently in the dermatome. Expression was also detected in migrating precursors of tongue muscle and in the limb buds.

Induction: Surface ectoderm and neural tube are the sources of inductive signals required for gene expression and for somite formation.

Sequence similarities: Contains 1 bHLH (basic helix-loop-helix) domain.