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Microsomal Glutathione S-Transferase 1 (MGST1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS951949

MBS951949 is a recombinant protein targeting Mgst1. Also known as Recombinant Rat Microsomal glutathione S-transferase 1 (Mgst1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Microsomal glutathione S-transferase 1 (Mgst1), Recombinant Protein
Full Product Name
Recombinant Rat Microsomal glutathione S-transferase 1 (Mgst1)
Product Gene Name
Mgst1 recombinant protein
Product Synonym Gene Name
Mgst1; Gst12
Product Synonym Names
Recombinant Microsomal glutathione S-transferase 1 (Mgst1); Microsomal glutathione S-transferase 1; Microsomal GST-1 EC= 2.5.1.18; Microsomal GST-I
Sequence
ADLKQLMDNE VLMAFTSYAT IILAKMMFLS SATAFQRLTN KVFANPEDCA GFGKGENAKK FLRTDEKVER VRRAHLNDLE NIVPFLGIGL LYSLSGPDLS TALIHFRIFV GARIYHTIAY LTPLPQPNRG LAFFVGYGVT LSMAYRLLRS RLYL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
17,472 Da
Sequence Positions
2-155
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 4; NC_005103.3 (236372225..236387452). Location: 4q44
3D Structure
ModBase 3D Structure for P08011
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Mgst1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Mgst1. It may not necessarily be applicable to this product.

NCBI GI #
19705453
NCBI GeneID
171341
NCBI Accession #
NP_599176.1
UniProt Primary Accession #
P08011
UniProt Related Accession #
P08011
GenBank Nucleotide #
NM_134349.3
NCBI Official Full Name
microsomal glutathione S-transferase 1
NCBI Official Synonym Full Names
microsomal glutathione S-transferase 1
NCBI Official Symbol
Mgst1
UniProt Protein Name
Microsomal glutathione S-transferase 1
UniProt Synonym Protein Names
Microsomal GST-I
Protein Family
Microsomal glutathione S-transferase
UniProt Gene Name
Mgst1
UniProt Synonym Gene Names
Gst12; Microsomal GST-1
UniProt Entry Name
MGST1_RAT
NCBI Protein Information
microsomal glutathione S-transferase 1; microsomal GST-1; microsomal GST-I

NCBI Summary for Mgst1

enzyme that catalyzes the transfer of glutathione onto hydrophobic substrates [RGD, Feb 2006]

UniProt Comments for Mgst1

MGST1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. Belongs to the MAPEG family.

Protein type: Endoplasmic reticulum; Membrane protein, peripheral; Mitochondrial; Membrane protein, integral; Transferase; EC 2.5.1.18; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Membrane protein, multi-pass; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione

Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; apical part of cell; mitochondrial inner membrane; integral to membrane; nucleus

Molecular Function: identical protein binding; protein homodimerization activity; glutathione transferase activity; glutathione binding; glutathione peroxidase activity

Biological Process: response to drug; glutathione metabolic process; Leydig cell differentiation; response to lipopolysaccharide; response to organic nitrogen
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Research Articles on Mgst1

1. Two doxorubicin derivatives/prodrugs (DNS-DOX; MNS-DOX) are substrates for MGST1; neoplasm drug resistance can be overcome in cell lines over-expressing recombinant MGST1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Mgst1 recombinant protein

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram

Diseases associated with Mgst1 recombinant protein

 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >14 publications with Mgst1 and Drug Toxicity
 Neoplasms Antibodies  >9 publications with Mgst1 and Neoplasms
 Inflammation Antibodies  >7 publications with Mgst1 and Inflammation
 Carcinoma Antibodies  >3 publications with Mgst1 and Carcinoma
 Lung Neoplasms Antibodies  >3 publications with Mgst1 and Lung Neoplasms
 Necrosis Antibodies  >3 publications with Mgst1 and Necrosis
 Lung Diseases Antibodies  >2 publications with Mgst1 and Lung Diseases
 Breast Neoplasms Antibodies  >1 publications with Mgst1 and Breast Neoplasms
 Fatty Liver Antibodies  >1 publications with Mgst1 and Fatty Liver
 Liver Diseases Antibodies  >1 publications with Mgst1 and Liver Diseases

Organs/Tissues associated with Mgst1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >37 publications with Mgst1 and Liver
 Lung Antibodies  >7 publications with Mgst1 and Lung
 Muscle Antibodies  >3 publications with Mgst1 and Muscle
 Brain Antibodies  >3 publications with Mgst1 and Brain
 Embryonic Tissue Antibodies  >2 publications with Mgst1 and Embryonic Tissue
 Eye Antibodies  >2 publications with Mgst1 and Eye
 Kidney Antibodies  >2 publications with Mgst1 and Kidney
 Prostate Antibodies  >2 publications with Mgst1 and Prostate
 Heart Antibodies  >2 publications with Mgst1 and Heart
 Ovary Antibodies  >1 publications with Mgst1 and Ovary
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