Human TMOD1 Recombinant Protein – Cat# MBS952131

Tropomodulin-1 (TMOD1) Human Recombinant Protein

Name: TMOD1 Recombinant Protein; Tropomodulin-1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS952131
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS952131

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tropomodulin-1 (TMOD1), Recombinant Protein

Full Product Name

Recombinant Human Tropomodulin-1 (TMOD1)

Product Gene Name

TMOD1 recombinant protein

Product Synonym Gene Name

TMOD1; D9S57E; TMOD

Product Synonym Names

Tropomodulin-1; Erythrocyte tropomodulin; E-Tmod

Sequence

MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ KDQTTKAPTG PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ KPLDPVLESV TLEPELEEAL ANASDAELCD IAAILGMHTL MSNQQYYQAL SSSSIMNKEG LNSVIKPTQY KPVPDEEPNS TDVEETLERI KNNDPKLEEV NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV AYALAEMLKE NKVLKTLNVE SNFISGAGIL RLVEALPYNT SLVEMKIDNQ SQPLGNKVEM EIVSMLEKNA TLLKFGYHFT QQGPRLRASN AMMNNNDLVR KRRLADLTGP IIPKCRSGV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

67.6 kDa

Sequence Positions

1-359. Full-Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

190930

3D Structure

ModBase 3D Structure for P28289

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TMOD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMOD1 purchase

MBS952131 is a recombinant protein targeting TMOD1. Also known as Recombinant Human Tropomodulin-1 (TMOD1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TMOD1. It may not necessarily be applicable to this product.

NCBI GI #

260763922

NCBI GeneID

7111

NCBI Accession #

NP_001159588.1

UniProt Primary Accession #

P28289

UniProt Secondary Accession #

Q9BUF1; B2RB77

UniProt Related Accession #

P28289

GenBank Nucleotide #

NM_001166116.1

NCBI Official Full Name

tropomodulin-1

NCBI Official Synonym Full Names

tropomodulin 1

NCBI Official Symbol

TMOD1

NCBI Official Synonym Symbols

TMOD; ETMOD; D9S57E

UniProt Protein Name

Tropomodulin-1

UniProt Synonym Protein Names

Erythrocyte tropomodulin; E-Tmod

Protein Family

Tropomodulin

UniProt Gene Name

TMOD1

UniProt Synonym Gene Names

D9S57E; TMOD; E-Tmod

UniProt Entry Name

TMOD1_HUMAN

NCBI Protein Information

tropomodulin-1; E-Tmod; e-tropomodulin; erythrocyte tropomodulin

NCBI Summary for TMOD1

This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

UniProt Comments for TMOD1

TMOD1: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. Belongs to the tropomodulin family.

Protein type: Motility/polarity/chemotaxis; Contractile; Cytoskeletal; Cell development/differentiation

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: signalosome; cortical cytoskeleton; membrane; cytosol; striated muscle thin filament

Molecular Function: actin filament binding; tropomyosin binding

Biological Process: myofibril assembly; muscle contraction; adult locomotory behavior; actin filament organization; pointed-end actin filament capping; muscle filament sliding

Research Articles on TMOD1

1. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TMOD1 recombinant protein

Reference Product	PubMed Publications
TPM3 recombinant protein	>48 publications with TMOD1 and TPM3
TPM1 recombinant protein	>2 publications with TMOD1 and TPM1
TNNT2 recombinant protein	>1 publications with TMOD1 and TNNT2

Pathways associated with TMOD1 recombinant protein

Products by Pathway	Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram

Diseases associated with TMOD1 recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>11 publications with TMOD1 and Cardiovascular Diseases
Hypertrophy Antibodies	>4 publications with TMOD1 and Hypertrophy
Disease Models, Animal Antibodies	>2 publications with TMOD1 and Disease Models, Animal
Drug Toxicity Antibodies	>1 publications with TMOD1 and Drug Toxicity
Memory Disorders Antibodies	>1 publications with TMOD1 and Memory Disorders
Fetal Death Antibodies	>1 publications with TMOD1 and Fetal Death
Weight Loss Antibodies	>1 publications with TMOD1 and Weight Loss
Learning Disorders Antibodies	>1 publications with TMOD1 and Learning Disorders
Inflammation Antibodies	>1 publications with TMOD1 and Inflammation

Organs/Tissues associated with TMOD1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>50 publications with TMOD1 and Muscle
Heart Antibodies	>25 publications with TMOD1 and Heart
Blood Antibodies	>17 publications with TMOD1 and Blood
Embryonic Tissue Antibodies	>11 publications with TMOD1 and Embryonic Tissue
Eye Antibodies	>9 publications with TMOD1 and Eye
Brain Antibodies	>9 publications with TMOD1 and Brain
Liver Antibodies	>3 publications with TMOD1 and Liver
Lung Antibodies	>2 publications with TMOD1 and Lung
Connective Tissue Antibodies	>1 publications with TMOD1 and Connective Tissue
Intestine Antibodies	>1 publications with TMOD1 and Intestine