5-Hydroxytryptamine Receptor 2c (HTR2C) Rat Recombinant Protein

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]

5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: cell surface; cell; integral to plasma membrane; plasma membrane; cytosol; external side of plasma membrane

Molecular Function: protein binding; serotonin binding; serotonin receptor activity; 5-HT2 receptor activity; drug binding

Biological Process: cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); behavioral fear response; G-protein signaling, phospholipase D activating pathway; behavioral response to nicotine; locomotory behavior; negative regulation of locomotion; feeding behavior; serotonin receptor signaling pathway; positive regulation of gamma-aminobutyric acid secretion; positive regulation of acetylcholine secretion; response to drug; organ regeneration; inositol phosphate-mediated signaling; serotonin receptor, phospholipase C activating pathway; regulation of corticotropin-releasing hormone secretion; positive regulation of phosphatidylinositol biosynthetic process; negative regulation of dopamine metabolic process; cellular calcium ion homeostasis; regulation of neurological process; G-protein signaling, coupled to cyclic nucleotide second messenger; release of sequestered calcium ion into cytosol; regulation of appetite; positive regulation of vasoconstriction; positive regulation of fat cell differentiation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain