Human ALOX5 Recombinant Protein – Cat# MBS952367

Arachidonate 5-Lipoxygenase (ALOX5) Human Recombinant Protein

Name: ALOX5 Recombinant Protein; Arachidonate 5-Lipoxygenase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS952367
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS952367

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Arachidonate 5-lipoxygenase (ALOX5), Recombinant Protein

Full Product Name

Recombinant Human Arachidonate 5-lipoxygenase (ALOX5)

Product Gene Name

ALOX5 recombinant protein

Sequence

MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY YYLSPDRIPN SVAI

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

56,291 Da

Sequence Positions

1-674, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

152390

3D Structure

ModBase 3D Structure for P09917

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ALOX5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALOX5 purchase

MBS952367 is a recombinant protein targeting ALOX5. Also known as Recombinant Human Arachidonate 5-lipoxygenase (ALOX5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ALOX5. It may not necessarily be applicable to this product.

NCBI GI #

4502057

NCBI GeneID

240

NCBI Accession #

NP_000689.1

UniProt Primary Accession #

P09917

UniProt Secondary Accession #

Q5JQ14; B7ZLS0; E5FPY5; E5FPY7; E5FPY8

UniProt Related Accession #

P09917

GenBank Nucleotide #

NM_000698.4

NCBI Official Full Name

arachidonate 5-lipoxygenase isoform 1

NCBI Official Synonym Full Names

arachidonate 5-lipoxygenase

NCBI Official Symbol

ALOX5

NCBI Official Synonym Symbols

5-LO; 5LPG; LOG5; 5-LOX

UniProt Protein Name

Arachidonate 5-lipoxygenase

Protein Family

Arachidonate 5-lipoxygenase

UniProt Gene Name

ALOX5

UniProt Synonym Gene Names

LOG5; 5-LO; 5-lipoxygenase

NCBI Protein Information

arachidonate 5-lipoxygenase

NCBI Summary for ALOX5

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

UniProt Comments for ALOX5

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Research Articles on ALOX5

1. Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells; the co-carcinogens decrease cell proliferation but enhance apoptosis, actions inhibited by knockdown of ALOX5 by RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ALOX5 recombinant protein

Reference Product	PubMed Publications
ALOX5AP recombinant protein	>195 publications with ALOX5 and ALOX5AP
COTL1 recombinant protein	>9 publications with ALOX5 and COTL1
MAPKAPK2 recombinant protein	>7 publications with ALOX5 and MAPKAPK2
GRB2 recombinant protein	>3 publications with ALOX5 and GRB2
TGFBRAP1 recombinant protein	>1 publications with ALOX5 and TGFBRAP1

Pathways associated with ALOX5 recombinant protein

Products by Pathway	Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Eicosanoid Synthesis Pathway antibodies	Eicosanoid Synthesis Pathway Diagram
IL-5 Signaling Pathway antibodies	IL-5 Signaling Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
Selenium Pathway antibodies	Selenium Pathway Diagram

Diseases associated with ALOX5 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>534 publications with ALOX5 and Inflammation
Neoplasms Antibodies	>305 publications with ALOX5 and Neoplasms
Asthma Antibodies	>235 publications with ALOX5 and Asthma
Lung Diseases Antibodies	>220 publications with ALOX5 and Lung Diseases
Atherosclerosis Antibodies	>112 publications with ALOX5 and Atherosclerosis
Necrosis Antibodies	>104 publications with ALOX5 and Necrosis
Edema Antibodies	>94 publications with ALOX5 and Edema
Drug Toxicity Antibodies	>88 publications with ALOX5 and Drug Toxicity
Neoplasms, Experimental Antibodies	>51 publications with ALOX5 and Neoplasms, Experimental
Pain Antibodies	>47 publications with ALOX5 and Pain

Organs/Tissues associated with ALOX5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1091 publications with ALOX5 and Blood
Lung Antibodies	>243 publications with ALOX5 and Lung
Brain Antibodies	>120 publications with ALOX5 and Brain
Muscle Antibodies	>113 publications with ALOX5 and Muscle
Bone Antibodies	>75 publications with ALOX5 and Bone
Heart Antibodies	>67 publications with ALOX5 and Heart
Kidney Antibodies	>64 publications with ALOX5 and Kidney
Bone Marrow Antibodies	>56 publications with ALOX5 and Bone Marrow
Intestine Antibodies	>45 publications with ALOX5 and Intestine
Prostate Antibodies	>37 publications with ALOX5 and Prostate