Human STIP1 Recombinant Protein – Cat# MBS952507

Stress-Induced-Phosphoprotein 1 (STIP1) Human Recombinant Protein

Name: STIP1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS952507
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS952507

Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). More details

$365 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Stress-induced-phosphoprotein 1 (STIP1), Recombinant Protein

Full Product Name

Recombinant Human Stress-induced-phosphoprotein 1

Product Gene Name

STIP1 recombinant protein

Product Synonym Names

Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521

Sequence

MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNPQLKE GLQNMEARLA ERKFMNPFNM PNLYQKLESD PRTRTLLSDP TYRELIEQLR NKPSDLGTKL QDPRIMTTLS VLLGVDLGSM DEEEEIATPP PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDTALKHYDK AKELDPTNMT YITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

78.6 kDa

Sequence Positions

1-543aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

605063

3D Structure

ModBase 3D Structure for P31948

Product Categories/Family for STIP1 recombinant protein

Signal Transduction

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for STIP1 recombinant protein

Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1.Honore B., Leffers H., Madsen P., Rasmussen H.H., Vandekerckhove J., Celis J.E.J. Biol. Chem. 267:8485-8491(1992)

Other Notes

Small volumes of STIP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STIP1 purchase

MBS952507 is a recombinant protein targeting STIP1. Also known as Recombinant Human Stress-induced-phosphoprotein 1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for STIP1. It may not necessarily be applicable to this product.

NCBI GI #

544063423

NCBI GeneID

10963

NCBI Accession #

NP_001269581.1

UniProt Primary Accession #

P31948

UniProt Secondary Accession #

Q3ZCU9; Q5TZU9; B4DM70; F5H0T1; G3XAD8

UniProt Related Accession #

P31948

GenBank Nucleotide #

NM_001282652.1

NCBI Official Full Name

stress-induced-phosphoprotein 1 isoform a

NCBI Official Synonym Full Names

stress induced phosphoprotein 1

NCBI Official Symbol

STIP1

NCBI Official Synonym Symbols

HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521

UniProt Protein Name

Stress-induced-phosphoprotein 1

UniProt Synonym Protein Names

Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521

Protein Family

Stress-induced-phosphoprotein

UniProt Gene Name

STIP1

UniProt Synonym Gene Names

STI1; Hop

UniProt Entry Name

STIP1_HUMAN

NCBI Protein Information

stress-induced-phosphoprotein 1

NCBI Summary for STIP1

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

UniProt Comments for STIP1

STI1: a protein that is apparently involved in the response to stress. Specifically interacts with the C-terminal tails of Hsp70 and Hsp90 via TPR1 and TPR2A domains. Deletion of STI1 reduces the activity of the glucocorticoid receptor, a Hsp90 target protein. Phosphorylated in vitro by p90RSK and casein kinase II.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; myelin sheath; nucleus; protein complex

Molecular Function: chaperone binding; Hsp70 protein binding; protein binding; protein C-terminus binding

Biological Process: response to stress

Research Articles on STIP1

1. Data confirmed the significant up-regulation of STIP1 in tumorous cholangiocytes relative to normal hepatocytes and non-tumorous cells and show prooved it as a reliable diagnostic biomarker when using immunohistochemistry.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STIP1 recombinant protein

Reference Product	PubMed Publications
HSPA8 recombinant protein	>6 publications with STIP1 and HSPA8
PRNP recombinant protein	>3 publications with STIP1 and PRNP
HSP90AA1 recombinant protein	>2 publications with STIP1 and HSP90AA1
AHSA1 recombinant protein	>1 publications with STIP1 and AHSA1

Pathways associated with STIP1 recombinant protein

Products by Pathway	Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram

Diseases associated with STIP1 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>8 publications with STIP1 and Inflammation
Nervous System Diseases Antibodies	>8 publications with STIP1 and Nervous System Diseases
Lung Diseases Antibodies	>6 publications with STIP1 and Lung Diseases
Brain Diseases Antibodies	>5 publications with STIP1 and Brain Diseases
Liver Diseases Antibodies	>4 publications with STIP1 and Liver Diseases
Disease Models, Animal Antibodies	>3 publications with STIP1 and Disease Models, Animal
Liver Neoplasms Antibodies	>3 publications with STIP1 and Liver Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with STIP1 and Cardiovascular Diseases
Necrosis Antibodies	>3 publications with STIP1 and Necrosis
Carcinoma, Hepatocellular Antibodies	>2 publications with STIP1 and Carcinoma, Hepatocellular

Organs/Tissues associated with STIP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>19 publications with STIP1 and Brain
Blood Antibodies	>18 publications with STIP1 and Blood
Liver Antibodies	>8 publications with STIP1 and Liver
Muscle Antibodies	>8 publications with STIP1 and Muscle
Eye Antibodies	>6 publications with STIP1 and Eye
Lung Antibodies	>6 publications with STIP1 and Lung
Nerve Antibodies	>6 publications with STIP1 and Nerve
Bone Antibodies	>6 publications with STIP1 and Bone
Heart Antibodies	>4 publications with STIP1 and Heart
Vascular Antibodies	>4 publications with STIP1 and Vascular