Tyrosine-Protein Phosphatase Non-Receptor Type 6 (PTPN6) Human Recombinant Protein

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hatopoiesis.

Protein tyrosine phosphatase containing SH2 domains characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.Yi T., Cleveland J.L., Ihle J.N.Mol. Cell. Biol. 12:836-846(1992) A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.Shen S.H., Bastien L., Posner B.I., Chretien P.Nature 352:736-739(1991) ErratumShen S.H., Bastien L., Posner B.I., Chretien P.Nature 353:868-868(1991) Isolation of a src homology 2-containing tyrosine phosphatase.Plutzky J., Neel B.G., Rosenberg R.D.Proc. Natl. Acad. Sci. 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Small volumes of PTPN6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS952590 is a recombinant protein targeting PTPN6. Also known as Recombinant Human Tyrosine-protein phosphatase non-receptor type 6. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.