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Host Cell Factor 1 (HCFC1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS952735

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at… More details

$865 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Host cell factor 1 (HCFC1), Recombinant Protein
Full Product Name
Recombinant Human Host cell factor 1 (HCFC1) , partial
Product Gene Name
HCFC1 recombinant protein
Sequence
ATEEAQALAI QAVLQAAQQA VMGTGEPMDT SEAAATVTQA ELGHLSAEGQ EGQATTIPIV LTQQELAALV QQQQLQEAQA QQQHHHLPTE ALAPADSLND PAIESNCLNE LAGTVPSTVA LLPSTATESL APSNTFVAPQ PVVVASPAKL QAAATLTEVA NGIESLGVKP DLPPPPSKAP MKKENQWFDV GVIKGTNVMV THYFLPPDDA V
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
213,405 Da
Sequence Positions
1626-1836aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
300019
3D Structure
ModBase 3D Structure for P51610
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HCFC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HCFC1 purchase

MBS952735 is a recombinant protein targeting HCFC1. Also known as Recombinant Human Host cell factor 1 (HCFC1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for HCFC1. It may not necessarily be applicable to this product.

NCBI GI #
98986457
NCBI GeneID
3054
NCBI Accession #
NP_005325.2
UniProt Primary Accession #
P51610
UniProt Secondary Accession #
Q6P4G5
UniProt Related Accession #
P51610
GenBank Nucleotide #
NM_005334.2
NCBI Official Full Name
host cell factor 1
NCBI Official Synonym Full Names
host cell factor C1
NCBI Official Symbol
HCFC1
NCBI Official Synonym Symbols
CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; PPP1R89
UniProt Protein Name
Host cell factor 1
UniProt Synonym Protein Names
C1 factor; CFF; VCAF; VP16 accessory protein
Protein Family
Host cell factor
UniProt Gene Name
HCFC1
UniProt Synonym Gene Names
HCF1; HFC1; HCF; HCF-1
NCBI Protein Information
host cell factor 1

UniProt Comments for HCFC1

Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655).
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Research Articles on HCFC1

1. Data show that Myc boxes (MbIV) is required for the association of MYC with the abundant transcriptional coregulator host cell factor-1 (HCF-1).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HCFC1 recombinant protein

 Reference Product  PubMed Publications
 JUN recombinant protein  >65 publications with HCFC1 and JUN
 SP1 recombinant protein  >36 publications with HCFC1 and SP1
 OGT recombinant protein  >6 publications with HCFC1 and OGT
 PDCD2 recombinant protein  >2 publications with HCFC1 and PDCD2
 EGR2 recombinant protein  >2 publications with HCFC1 and EGR2
 SIN3A recombinant protein  >1 publications with HCFC1 and SIN3A
 SETD7 recombinant protein  >1 publications with HCFC1 and SETD7
 PPARGC1A recombinant protein  >1 publications with HCFC1 and PPARGC1A

Pathways associated with HCFC1 recombinant protein

 Products by Pathway  Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Mitochondrial Gene Expression Pathway antibodies  Mitochondrial Gene Expression Pathway Diagram

Diseases associated with HCFC1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >48 publications with HCFC1 and Neoplasms
 Necrosis Antibodies  >11 publications with HCFC1 and Necrosis
 Adenocarcinoma Antibodies  >7 publications with HCFC1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >7 publications with HCFC1 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with HCFC1 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >6 publications with HCFC1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >5 publications with HCFC1 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >4 publications with HCFC1 and Kidney Diseases
 Breast Neoplasms Antibodies  >4 publications with HCFC1 and Breast Neoplasms
 Lung Diseases Antibodies  >2 publications with HCFC1 and Lung Diseases

Organs/Tissues associated with HCFC1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >99 publications with HCFC1 and Blood
 Liver Antibodies  >24 publications with HCFC1 and Liver
 Brain Antibodies  >22 publications with HCFC1 and Brain
 Kidney Antibodies  >15 publications with HCFC1 and Kidney
 Embryonic Tissue Antibodies  >11 publications with HCFC1 and Embryonic Tissue
 Lung Antibodies  >10 publications with HCFC1 and Lung
 Muscle Antibodies  >9 publications with HCFC1 and Muscle
 Vascular Antibodies  >8 publications with HCFC1 and Vascular
 Thymus Antibodies  >8 publications with HCFC1 and Thymus
 Bone Antibodies  >7 publications with HCFC1 and Bone
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