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B-Lymphocyte Antigen CD20 (MS4A1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS952945

This protein may be involved in the regulation of B-cell activation and proliferation. More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
B-lymphocyte antigen CD20 (Ms4a1), Recombinant Protein
Full Product Name
Recombinant Mouse B-lymphocyte antigen CD20
Product Gene Name
Ms4a1 recombinant protein
Product Synonym Names
B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; CD20
Sequence
VIMSSLSLFA AISGIILSIM DILNMTLSHF LKMRRLELIQ TSKPYVDIYD CEPSNSSEKN SPSTQYCNSI QSVFLGILSA MLISAFFQKL VTAGIVENEW KRMCTRSKSN VVLLSAGEKN EQTIKMKEEI IELSGVSSQP KNEEEIEIIP VQEEEEEEAE INFPAPPQEQ ESLPVENEIA P
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
22.3 kDa
Sequence Positions
111-291aa; partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P19437
Production Note
Special Offer: The Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Ms4a1 recombinant protein

Mouse MS4A1 Recombinant Protein – Cat# MBS952945

Product References and Citations for Ms4a1 recombinant protein

Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19.Tedder T.F., Klejman G., Disteche C.M., Adler D.A., Schlossman S.F., Saito H.J. Immunol. 141:4388-4394(1988) The oligomeric nature of the murine Fc epsilon RII/CD23. Implications for function.Dierks S.E., Bartlett W.C., Edmeades R.L., Gould H.J., Rao M., Conrad D.H.J. Immunol. 150:2372-2382(1993) CD20 deficiency in humans results in impaired T cell-independent antibody responses.Kuijpers T.W., Bende R.J., Baars P.A., Grummels A., Derks I.A.M., Dolman K.M., Beaumont T., Tedder T.F., van Noesel C.J.M., Eldering E., van Lier R.A.W.J. Clin. Invest. 120:214-222(2010)

Other Notes

Small volumes of Ms4a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ms4a1 purchase

MBS952945 is a recombinant protein targeting Ms4a1. Also known as Recombinant Mouse B-lymphocyte antigen CD20. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Ms4a1. It may not necessarily be applicable to this product.

NCBI GI #
6671710
NCBI GeneID
12482
NCBI Accession #
NP_031667.1
UniProt Primary Accession #
P19437
UniProt Related Accession #
P19437
GenBank Nucleotide #
NM_007641.5
NCBI Official Full Name
B-lymphocyte antigen CD20
NCBI Official Synonym Full Names
membrane-spanning 4-domains, subfamily A, member 1
NCBI Official Symbol
Ms4a1
NCBI Official Synonym Symbols
Cd20; Ly-44; Ms4a2; AA960661
UniProt Protein Name
B-lymphocyte antigen CD20
UniProt Synonym Protein Names
B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
Protein Family
B-lymphocyte antigen
UniProt Gene Name
Ms4a1
UniProt Synonym Gene Names
Cd20; Ly-44; Ms4a2
UniProt Entry Name
CD20_MOUSE
NCBI Protein Information
B-lymphocyte antigen CD20

UniProt Comments for Ms4a1

MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.

Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-pass

Cellular Component: external side of plasma membrane; extracellular space; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: epidermal growth factor receptor binding; protein binding

Biological Process: B cell activation
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Research Articles on Ms4a1

1. this study demonstrates a role for CD20 in B cell activation and T-dependent humoral immunity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Ms4a1 recombinant protein

 Reference Product  PubMed Publications
 Cd19 recombinant protein  >5 publications with Ms4a1 and Cd19
 Bank1 recombinant protein  >2 publications with Ms4a1 and Bank1
 Cd79b recombinant protein  >2 publications with Ms4a1 and Cd79b
 Cd79a recombinant protein  >1 publications with Ms4a1 and Cd79a

Pathways associated with Ms4a1 recombinant protein

 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with Ms4a1 recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with Ms4a1 and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with Ms4a1 and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >1 publications with Ms4a1 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >1 publications with Ms4a1 and Breast Neoplasms
 Atherosclerosis Antibodies  >1 publications with Ms4a1 and Atherosclerosis
 Lung Diseases Antibodies  >1 publications with Ms4a1 and Lung Diseases
 Lung Neoplasms Antibodies  >1 publications with Ms4a1 and Lung Neoplasms

Organs/Tissues associated with Ms4a1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with Ms4a1 and Kidney
 Bone Antibodies  >1 publications with Ms4a1 and Bone
 Embryonic Tissue Antibodies  >1 publications with Ms4a1 and Embryonic Tissue
 Bone Marrow Antibodies  >1 publications with Ms4a1 and Bone Marrow
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