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Signal Transducer and Activator of Transcription 5a (STAT5A) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS953134

This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell… More details

$1675 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Signal transducer and activator of transcription 5A (Stat5a), Recombinant Protein
Full Product Name
Recombinant Mouse Signal transducer and activator of transcription 5A (Stat5a)
Product Gene Name
Stat5a recombinant protein
Sequence
MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRGQATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV REANNCSSPA GVLVDAMSQK HLQINQRFEE LRLITQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLG QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNI SSNHLEDYNS MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRD FSIRSLADRL GDLNYLIYVF PDRPKDEVFA KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS TDAGASATYM DQAPSPVVCP QPHYNMYPPN PDPVLDQDGE FDLDESMDVA RHVEELLRRP MDSLDARLSP PAGLFTSARS SLS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
90,831 Da
Sequence Positions
1-793. Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P42230
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Stat5a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Stat5a purchase

MBS953134 is a recombinant protein targeting Stat5a. Also known as Recombinant Mouse Signal transducer and activator of transcription 5A (Stat5a). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Stat5a. It may not necessarily be applicable to this product.

NCBI GI #
6755672
NCBI GeneID
20850
NCBI Accession #
NP_035618.1
UniProt Primary Accession #
P42230
UniProt Related Accession #
P42230
GenBank Nucleotide #
NM_011488.3
NCBI Official Full Name
signal transducer and activator of transcription 5A isoform 1
NCBI Official Synonym Full Names
signal transducer and activator of transcription 5A
NCBI Official Symbol
Stat5a
NCBI Official Synonym Symbols
STAT5; AA959963
UniProt Protein Name
Signal transducer and activator of transcription 5A
UniProt Synonym Protein Names
Mammary gland factor
Protein Family
Signal transducer and activator of transcription
UniProt Gene Name
Stat5a
UniProt Synonym Gene Names
Mgf; Mpf
NCBI Protein Information
signal transducer and activator of transcription 5A

UniProt Comments for Stat5a

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
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Research Articles on Stat5a

1. Results suggest activation of H2AX via promoter demethylation in specific populations of basal mammary cells that is induced by a signal from neighboring luminal cells with hyper STAT5 activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Stat5a recombinant protein

 Reference Product  PubMed Publications
 Jak2 recombinant protein  >162 publications with Stat5a and Jak2
 Src recombinant protein  >56 publications with Stat5a and Src
 Jak3 recombinant protein  >45 publications with Stat5a and Jak3
 Jak1 recombinant protein  >40 publications with Stat5a and Jak1
 Bcl2l1 recombinant protein  >25 publications with Stat5a and Bcl2l1
 Socs1 recombinant protein  >18 publications with Stat5a and Socs1
 Flt3 recombinant protein  >16 publications with Stat5a and Flt3
 Tyk2 recombinant protein  >15 publications with Stat5a and Tyk2
 Erbb4 recombinant protein  >13 publications with Stat5a and Erbb4
 Socs3 recombinant protein  >13 publications with Stat5a and Socs3

Pathways associated with Stat5a recombinant protein

 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram

Diseases associated with Stat5a recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >67 publications with Stat5a and Breast Neoplasms
 Carcinoma Antibodies  >59 publications with Stat5a and Carcinoma
 Kidney Diseases Antibodies  >43 publications with Stat5a and Kidney Diseases
 Disease Models, Animal Antibodies  >38 publications with Stat5a and Disease Models, Animal
 Inflammation Antibodies  >34 publications with Stat5a and Inflammation
 Neoplasms, Experimental Antibodies  >31 publications with Stat5a and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >31 publications with Stat5a and Adenocarcinoma
 Mammary Neoplasms, Animal Antibodies  >25 publications with Stat5a and Mammary Neoplasms, Animal
 Cardiovascular Diseases Antibodies  >25 publications with Stat5a and Cardiovascular Diseases
 Liver Diseases Antibodies  >21 publications with Stat5a and Liver Diseases

Organs/Tissues associated with Stat5a recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Mammary Gland Antibodies  >147 publications with Stat5a and Mammary Gland
 Liver Antibodies  >75 publications with Stat5a and Liver
 Bone Antibodies  >71 publications with Stat5a and Bone
 Bone Marrow Antibodies  >59 publications with Stat5a and Bone Marrow
 Kidney Antibodies  >52 publications with Stat5a and Kidney
 Lung Antibodies  >40 publications with Stat5a and Lung
 Brain Antibodies  >32 publications with Stat5a and Brain
 Spleen Antibodies  >22 publications with Stat5a and Spleen
 Adipose Tissue Antibodies  >17 publications with Stat5a and Adipose Tissue
 Skin Antibodies  >17 publications with Stat5a and Skin
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