Mouse MYT1L Recombinant Protein – Cat# MBS953140

Myelin Transcription Factor 1-Like Protein (MYT1L) Mouse Recombinant Protein

Name: MYT1L Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS953140
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS953140

MBS953140 is a recombinant protein targeting Myt1l. Also known as Recombinant Mouse Myelin transcription factor 1-like protein (Myt1l) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Myelin transcription factor 1-like protein (Myt1l), Recombinant Protein

Full Product Name

Recombinant Mouse Myelin transcription factor 1-like protein (Myt1l) , partial

Product Gene Name

Myt1l recombinant protein

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

55,245 Da

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P97500

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Myt1l recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Myt1l. It may not necessarily be applicable to this product.

NCBI GI #

148271077

NCBI GeneID

17933

NCBI Accession #

NP_001087244.1

UniProt Primary Accession #

P97500

UniProt Secondary Accession #

O08996; Q33DP0; Q8C643; Q8C7L4; Q8CHB4; A2RRK5; D3Z1P7

UniProt Related Accession #

P97500

GenBank Nucleotide #

NM_001093775.1

NCBI Official Full Name

myelin transcription factor 1-like protein isoform 1

NCBI Official Synonym Full Names

myelin transcription factor 1-like

NCBI Official Symbol

Myt1l

NCBI Official Synonym Symbols

Nztf1; Pmng1; Png-1; mKIAA1106; 2900046C06Rik; 2900093J19Rik; C630034G21Rik

UniProt Protein Name

Myelin transcription factor 1-like protein

UniProt Synonym Protein Names

Neural zinc finger factor 1

Protein Family

Myelin transcription factor 1-like protein

UniProt Gene Name

Myt1l

UniProt Synonym Gene Names

NZF-1

NCBI Protein Information

myelin transcription factor 1-like protein

UniProt Comments for Myt1l

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941).

Research Articles on Myt1l

1. Depletion of Myt1l in primary postmitotic neurons de-repressed non-neuronal programs and impaired neuronal gene expression and function, indicating that many somatic lineage programs are actively and persistently repressed by Myt1l to maintain neuronal identity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Myt1l recombinant protein

Reference Product	PubMed Publications
FLNA recombinant protein	>12 publications with Myt1l and FLNA

Organs/Tissues associated with Myt1l recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>14 publications with Myt1l and Brain
Embryonic Tissue Antibodies	>3 publications with Myt1l and Embryonic Tissue
Pancreas Antibodies	>1 publications with Myt1l and Pancreas
Spinal Cord Antibodies	>1 publications with Myt1l and Spinal Cord