Proto-Oncogene Wnt-3 (WNT3) Mouse Recombinant Protein

WNT3: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA). Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. Belongs to the Wnt family.

Protein type: Secreted; Oncoprotein; Secreted, signal peptide

Cellular Component: cytoplasm; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: frizzled binding; protein binding; protein domain specific binding; receptor binding

Biological Process: anatomical structure formation; anterior/posterior axis specification; anterior/posterior pattern formation; axon guidance; cell fate commitment; cell morphogenesis; cell-cell signaling; dorsal/ventral axis specification; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; gamete generation; limb bud formation; limb development; mesoderm formation; multicellular organismal development; negative regulation of axon extension involved in axon guidance; organ morphogenesis; positive regulation of collateral sprouting in the absence of injury; positive regulation of Wnt receptor signaling pathway; signal transduction; Spemann organizer formation at the anterior end of the primitive streak; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin