Collagen Alpha-2(iv) Chain Protein Recombinant Protein

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

Small volumes of Collagen alpha-2(IV) chain protein recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Based on the Gene database nucleotide sequence, Pubmed searchable references, and Uniprotkb information, MyBiosource recombinant human collagen alpha-2 type IV has the correct annotation protein sequence. Alpha 2 IV collagen is purified using His tagging protocols following expression in E coli cells. As one of the key constituents of the glomerular basement membrane in kidney structure from mouse to human, this particular col chain protein type alpha-2 is bundled with 2 other family members into a woven fibrous mesh. Individuals with mutations of this protein have been diagnosed with a progressive kidney disease, Alport syndrome. Early research into disease mechanisms caused by mutated alpha 2 IV, 3 IV 4 IV and 5 IV chains of collagen may provide some translation into a clear drug discovery pathway with collagen as a target. This protein is available in convenient sizes for multiple cell uses, which are described in the included href manual.