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Dynamin-Like 120 Kda Protein, Mitochondrial (OPA1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS953425

MBS953425 is a recombinant protein targeting Opa1. Also known as Recombinant Mouse Dynamin-like 120 kDa protein, mitochondrial (Opa1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dynamin-like 120 kDa protein, mitochondrial (Opa1), Recombinant Protein
Full Product Name
Recombinant Mouse Dynamin-like 120 kDa protein, mitochondrial (Opa1)
Product Gene Name
Opa1 recombinant protein
Product Synonym Gene Name
Opa1
Product Synonym Names
Recombinant Dynamin-like 120 kDa protein, mitochondrial (Opa1); Dynamin-like 120 kDa protein, mitochondrial; Large GTP-binding protein; LargeG Optic atrophy protein 1 homolog Cleaved into the following chain: 1. Dynamin-like 120 kDa protein, form S1
Sequence
ATDHGSESDK HYRKVSDKEK IDQLQEELLH TQLKYQRILE RLEKENKELR KLVLQKDDKG IHHRKLKKSL IDMYSEVLDV LSDYDASYNT QDHLPRVVVV GDQSAGKTSV LEMIAQARIF PRGSGEMMTR SPVKVTLSEG PHHVALFKDS SREFDLTKEE DLAALRHEIE LRMRKNVKEG CTVSPETISL NVKGPGLQRM VLVDLPGVIN TVTSGMAPDT KETIFSISKA YMQNPNAIIL CIQDGSVDAE RSIVTDLVSQ MDPHGRRTIF VLTKVDLAEK NVASPSRIQQ IIEGKLFPMK ALGYFAVVTG KGNSSESIEA IREYEEEFFQ NSKLLKTSML KAHQVTTRNL SLAVSDCFWK MVRESVEQQA DSFKATRFNL ETEWKNNYPR LRELDRNELF EKAKNEILDE VISLSQVTPK HWEEILQQSL WERVSTHVIE NIYLPAAQTM NSGTFNTTVD IKLKQWTDKQ LPNKAVEVAW ETLQEEFSRF MTEPKGKEHD DIFDKLKEAV KEESIKRHKW NDFAEDSLRV IQHNALEDRS ISDKQQWDAA IYFMEEALQG RLKDTENAIE NMIGPDWKKR WMYWKNRTQE QCVHNETKNE LEKMLKVNDE HPAYLASDEI TTVRKNLESR GVEVDPSLIK DTWHQVYRRH FLKTALNHCN LCRRGFYYYQ RHFIDSELEC NDVVLFWRIQ RMLAITANTL RQQLTNTEVR RLEKNVKEVL EDFAEDGEKK VKLLTGKRVQ LAEDLKKVRE IQEKLDAFIE ALHQEK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
111,339 Da
Sequence Positions
195-960
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 16; NC_000082.6 (29579334..29654602). Location: 16 B2; 16 20.65 cM
3D Structure
ModBase 3D Structure for P58281
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Opa1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Opa1. It may not necessarily be applicable to this product.

NCBI GI #
19526960
NCBI GeneID
74143
NCBI Accession #
NP_598513.1
UniProt Primary Accession #
P58281
UniProt Secondary Accession #
Q3ULA5; Q8BKU7; Q8BLL3; Q8BM08; Q8R3J7; A6H6Q3
UniProt Related Accession #
P58281
GenBank Nucleotide #
NM_133752.3
NCBI Official Full Name
dynamin-like 120 kDa protein, mitochondrial isoform 2
NCBI Official Synonym Full Names
optic atrophy 1
NCBI Official Symbol
Opa1
NCBI Official Synonym Symbols
lilr3; AI225888; AI847218; mKIAA0567; 1200011N24Rik
UniProt Protein Name
Dynamin-like 120 kDa protein, mitochondrial
UniProt Synonym Protein Names
Large GTP-binding protein; LargeG; Optic atrophy protein 1 homolog
Protein Family
Dynamin-like 120 kDa protein
UniProt Gene Name
Opa1
UniProt Synonym Gene Names
LargeG
UniProt Entry Name
OPA1_MOUSE
NCBI Protein Information
dynamin-like 120 kDa protein, mitochondrial; largeG; optic atrophy 1 homolog; large GTP-binding protein; optic atrophy protein 1 homolog

UniProt Comments for Opa1

OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Mitochondrial; Apoptosis; Hydrolase; EC 3.6.5.5

Cellular Component: nucleoplasm; mitochondrial crista; mitochondrial outer membrane; membrane; mitochondrion; cytoplasm; dendrite; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space

Molecular Function: GTPase activity; protein binding; GTP binding; hydrolase activity; nucleotide binding

Biological Process: inner mitochondrial membrane organization and biogenesis; positive regulation of neuron maturation; mitochondrion organization and biogenesis; mitochondrial genome maintenance; visual perception; mitochondrial fusion; apoptosis; neural tube closure; response to stimulus
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Research Articles on Opa1

1. OPA1 plays an important role in mitochondrial morphology and mitochondrial permeability transition pore functioning.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Opa1 recombinant protein

 Disease Name  Pubmed Publications
 Optic atrophy 1 Antibodies  >207 publications with Opa1 and Optic atrophy 1
 Mitochondrial Diseases Antibodies  >182 publications with Opa1 and Mitochondrial Diseases
 Optic Atrophy, Autosomal Dominant Antibodies  >176 publications with Opa1 and Optic Atrophy, Autosomal Dominant
 Disease Models, Animal Antibodies  >24 publications with Opa1 and Disease Models, Animal
 Vision Disorders Antibodies  >23 publications with Opa1 and Vision Disorders
 Optic atrophy 1 and deafness Antibodies  >12 publications with Opa1 and Optic atrophy 1 and deafness
 Drug Toxicity Antibodies  >9 publications with Opa1 and Drug Toxicity
 Heart Diseases Antibodies  >8 publications with Opa1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >7 publications with Opa1 and Cardiovascular Diseases
 Parkinsonian Disorders Antibodies  >5 publications with Opa1 and Parkinsonian Disorders

Organs/Tissues associated with Opa1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >81 publications with Opa1 and Eye
 Muscle Antibodies  >49 publications with Opa1 and Muscle
 Brain Antibodies  >47 publications with Opa1 and Brain
 Blood Antibodies  >24 publications with Opa1 and Blood
 Heart Antibodies  >22 publications with Opa1 and Heart
 Skin Antibodies  >8 publications with Opa1 and Skin
 Embryonic Tissue Antibodies  >7 publications with Opa1 and Embryonic Tissue
 Liver Antibodies  >6 publications with Opa1 and Liver
 Spinal Cord Antibodies  >4 publications with Opa1 and Spinal Cord
 Pancreas Antibodies  >3 publications with Opa1 and Pancreas
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