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Orexin Receptor Type 1 (HCRTR1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS953549

MBS953549 is a recombinant protein targeting Hcrtr1. Also known as Recombinant Rat Orexin receptor type 1 (Hcrtr1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Orexin receptor type 1 (Hcrtr1), Recombinant Protein
Full Product Name
Recombinant Rat Orexin receptor type 1 (Hcrtr1)
Product Gene Name
Hcrtr1 recombinant protein
Product Synonym Gene Name
Hcrtr1
Product Synonym Names
Recombinant Orexin receptor type 1 (Hcrtr1); Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R; Hypocretin receptor type 1
Sequence
MEPSATPGAQ PGVPTSSGEP FHLPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFLIA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAVMVPQA AVMECSSVLP ELANRTRLFS VCDERWADEL YPKIYHSCFF FVTYLAPLGL MGMAYFQIFR KLWGPQIPGT TSALVRNWKR PSEQLEAQHQ GLCTEPQPRA RAFLAEVKQM RARRKTAKML MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPSSSARHKS LSLQSRCSVS KVSEHVVLTT VTTVLS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
46,800 Da
Sequence Positions
1-416
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 5; NC_005104.3 (152064507..152073882, complement). Location: 5q36
3D Structure
ModBase 3D Structure for P56718
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Hcrtr1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Hcrtr1. It may not necessarily be applicable to this product.

NCBI GI #
6981018
NCBI GeneID
25593
NCBI Accession #
NP_037196.1
UniProt Primary Accession #
P56718
UniProt Related Accession #
P56718
GenBank Nucleotide #
NM_013064.1
NCBI Official Full Name
orexin receptor type 1
NCBI Official Synonym Full Names
hypocretin (orexin) receptor 1
NCBI Official Symbol
Hcrtr1
NCBI Official Synonym Symbols
Hctr1
UniProt Protein Name
Orexin receptor type 1
UniProt Synonym Protein Names
Hypocretin receptor type 1
Protein Family
Orexin receptor
UniProt Gene Name
Hcrtr1
UniProt Synonym Gene Names
Ox-1-R; Ox1-R; Ox1R
UniProt Entry Name
OX1R_RAT
NCBI Protein Information
orexin receptor type 1; ox1r; ox1-R; ox-1-R; hypocretin receptor 1; hypocretin receptor type 1

NCBI Summary for Hcrtr1

neuropeptide receptor that binds orexin A; mediates orexin A modulation of the sleep-wake cycle [RGD, Feb 2006]

UniProt Comments for Hcrtr1

HCRTR1: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to plasma membrane

Molecular Function: neuropeptide receptor activity; orexin receptor activity; peptide hormone binding

Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; neuropeptide signaling pathway; feeding behavior; regulation of circadian sleep/wake cycle, sleep; cellular response to hormone stimulus
Show more

Research Articles on Hcrtr1

1. Orexin receptor type 1 antagonism reduces heroin self-administration, supporting a role for orexin in cue-triggered drug relapse.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Hcrtr1 recombinant protein

 Reference Product  PubMed Publications
 Hcrt recombinant protein  >10 publications with Hcrtr1 and Hcrt

Pathways associated with Hcrtr1 recombinant protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway antibodies  Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with Hcrtr1 recombinant protein

 Disease Name  Pubmed Publications
 Narcolepsy Antibodies  >7 publications with Hcrtr1 and Narcolepsy
 Nervous System Diseases Antibodies  >7 publications with Hcrtr1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with Hcrtr1 and Disease Models, Animal
 Central Nervous System Diseases Antibodies  >1 publications with Hcrtr1 and Central Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with Hcrtr1 and Brain Diseases

Organs/Tissues associated with Hcrtr1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with Hcrtr1 and Brain
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