Rat GJA3 Recombinant Protein – Cat# MBS953731

Gap Junction Alpha-3 Protein (GJA3) Rat Recombinant Protein

Name: GJA3 Recombinant Protein; Gap Junction Alpha-3 Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS953731
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS953731

MBS953731 is a recombinant protein targeting Gja3. Also known as Recombinant Rat Gap junction alpha-3 protein (Gja3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Gap junction alpha-3 protein (Gja3), Recombinant Protein

Full Product Name

Recombinant Rat Gap junction alpha-3 protein (Gja3)

Product Gene Name

Gja3 recombinant protein

Product Synonym Gene Name

Gja3; Cxn-46

Product Synonym Names

Recombinant Gap junction alpha-3 protein (Gja3); Gap junction alpha-3 protein; Connexin-46; Cx46

Sequence

GDWSFLGRLL ENAQEHSTVI GKVWLTVLFI FRILVLGAAA EEVWGDEQSD FTCNTQQPGC ENVCYDRAFP ISHIRFWALQ IIFVSTPTLI YLGHVLHIVR MEEKKKEREE ELLRRDNPQH GRGREPMRTG SPRDPPLRDD RGKVRIAGAL LRTYVFNIIF KTLFEVGFIA GQYFLYGFQL QPLYRCDRWP CPNTVDCFIS RPTEKTIFVI FMLAVACASL VLNMLEIYHL GWKKLKQGVT NHFNPDASEV RHKPLDPLSE AANSGPPSVS IGLPPYYTHP ACPTVQGKAT GFPGAPLLPA DFTVVTLNDA QGRGHPVKHC NGHHLTTEQN WASLGAEPQT PASKPSSAAS SPHGRKGLTD SSGSSLEESA LVVTPEGEQA LATTVEMHSP PLVLLDPERS SKSSSGRARP GDLAI

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

46,013 Da

Sequence Positions

2-416

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 15; NC_005114.3 (41147135..41172588, complement). Location: 15p12

3D Structure

ModBase 3D Structure for P29414

Species

Rattus norvegicus (Rat)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Gja3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Gja3. It may not necessarily be applicable to this product.

NCBI GI #

13242279

NCBI GeneID

79217

NCBI Accession #

NP_077352.1

UniProt Primary Accession #

P29414

UniProt Related Accession #

P29414

GenBank Nucleotide #

NM_024376.2

NCBI Official Full Name

gap junction alpha-3 protein

NCBI Official Synonym Full Names

gap junction protein, alpha 3

NCBI Official Symbol

Gja3

UniProt Protein Name

Gap junction alpha-3 protein

UniProt Synonym Protein Names

Connexin-46

Protein Family

Gap junction alpha-3 protein

UniProt Gene Name

Gja3

UniProt Synonym Gene Names

Cxn-46; Cx46

UniProt Entry Name

CXA3_RAT

NCBI Protein Information

gap junction alpha-3 protein; cx46; connexin 46; connexin-46; gap junction membrane channel protein alpha 3

NCBI Summary for Gja3

lens gap junction protein; oligomerizes into intercellular channels and functions to exchange low molecular weight metabolites and ions between adjacent cells; induces voltage-gated currents in nonjunctional plasma membrane [RGD, Feb 2006]

UniProt Comments for Gja3

Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure: A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.

Tissue specificity: Most abundant in lens, but also present in heart and kidney.

Sequence similarities: Belongs to the connexin family. Alpha-type (group II) subfamily.

Research Articles on Gja3

1. Cx43 and Cx46 have novel functions in regulating each other's expression and turnover in a reciprocal manner in addition to their conventional roles as gap junction proteins in lens cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Gja3 recombinant protein

Products by Pathway	Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram

Diseases associated with Gja3 recombinant protein

Disease Name	Pubmed Publications
Hearing Loss Antibodies	>2 publications with Gja3 and Hearing Loss
Abnormalities, Multiple Antibodies	>2 publications with Gja3 and Abnormalities, Multiple
Skin Diseases Antibodies	>1 publications with Gja3 and Skin Diseases
CATARACT, ZONULAR PULVERULENT 3 Antibodies	>1 publications with Gja3 and CATARACT, ZONULAR PULVERULENT 3

Organs/Tissues associated with Gja3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>2 publications with Gja3 and Heart