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Lupus La Protein (SSB) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS953836

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting th from exonuclease digestion and facilitating their folding and maturation. More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lupus La protein (SSB), Recombinant Protein
Full Product Name
Recombinant Human Lupus La protein (SSB)
Product Gene Name
SSB recombinant protein
Product Synonym Names
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
Sequence
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LEDKGQVLNI QMRRTLHKAF KGSIFVVFDS IESAKKFVET PGQKYKETDL LILFKDDYFA KKNEERKQNK VEAKLRAKQE QEAKQKLEED AEMKSLEEKI GCLLKFSGDL DDQTCREDLH ILFSNHGEIK WIDFVRGAKE GIILFKEKAK EALGKAKDAN NGNLQLRNKE VTWEVLEGEV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQPGS GKGKVQFQGK KTKFASDDEH DEHDENGATG PVKRAREETD KEEPASKQQK TENGAGDQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
50.8 kDa
Sequence Positions
1-408aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
109090
3D Structure
ModBase 3D Structure for P05455
Production Note
Special Offer: The Baculovirus, E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. Baculovirus, E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Baculovirus, E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Baculovirus, E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for SSB recombinant protein

Epigenetics and Nuclear Signaling
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of SSB recombinant protein

Human SSB Recombinant Protein – Cat# MBS953836

Product References and Citations for SSB recombinant protein

Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.Chan E.K.L., Sullivan K.F., Tan E.M.Nucleic Acids Res. 17:2233-2244(1989)

Other Notes

Small volumes of SSB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SSB purchase

MBS953836 is a recombinant protein targeting SSB. Also known as Recombinant Human Lupus La protein (SSB). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SSB. It may not necessarily be applicable to this product.

NCBI GI #
659667952
NCBI GeneID
6741
NCBI Accession #
NP_001281074.1
UniProt Primary Accession #
P05455
UniProt Secondary Accession #
Q15367; Q53XJ4
UniProt Related Accession #
P05455
GenBank Nucleotide #
NM_001294145.1
NCBI Official Full Name
lupus La protein
NCBI Official Synonym Full Names
Sjogren syndrome antigen B
NCBI Official Symbol
SSB
NCBI Official Synonym Symbols
La; LARP3; La/SSB
UniProt Protein Name
Lupus La protein
UniProt Synonym Protein Names
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
Protein Family
Heat shock protein
UniProt Gene Name
SSB
UniProt Synonym Gene Names
SS-B
UniProt Entry Name
LA_HUMAN
NCBI Protein Information
lupus La protein

NCBI Summary for SSB

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
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UniProt Comments for SSB

SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nuclear chromosome, telomeric region; ribonucleoprotein complex

Molecular Function: mRNA binding; nucleotide binding; protein binding; tRNA binding

Biological Process: histone mRNA metabolic process; tRNA modification
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Research Articles on SSB

1. At the 3' UTR, HUR facilitates circularization of the viral genome through interaction with another host factor, La, which is critical for replication.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SSB recombinant protein

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 RNA Polymerase III Abortive And Retractive Initiation Pathway antibodies  RNA Polymerase III Abortive And Retractive Initiation Pathway Diagram
 RNA Polymerase III Transcription Pathway antibodies  RNA Polymerase III Transcription Pathway Diagram
 RNA Polymerase III Transcription Termination Pathway antibodies  RNA Polymerase III Transcription Termination Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram

Diseases associated with SSB recombinant protein

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >201 publications with SSB and Heart Diseases
 Vascular Diseases Antibodies  >98 publications with SSB and Vascular Diseases
 Inflammation Antibodies  >76 publications with SSB and Inflammation
 Kidney Diseases Antibodies  >54 publications with SSB and Kidney Diseases
 Neoplasms, Experimental Antibodies  >51 publications with SSB and Neoplasms, Experimental
 Weight Gain Antibodies  >50 publications with SSB and Weight Gain
 Fibrosis Antibodies  >42 publications with SSB and Fibrosis
 Necrosis Antibodies  >42 publications with SSB and Necrosis
 Hypertension Antibodies  >37 publications with SSB and Hypertension
 Pain Antibodies  >35 publications with SSB and Pain

Organs/Tissues associated with SSB recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >687 publications with SSB and Blood
 Heart Antibodies  >264 publications with SSB and Heart
 Skin Antibodies  >169 publications with SSB and Skin
 Salivary Gland Antibodies  >163 publications with SSB and Salivary Gland
 Liver Antibodies  >142 publications with SSB and Liver
 Connective Tissue Antibodies  >137 publications with SSB and Connective Tissue
 Mouth Antibodies  >126 publications with SSB and Mouth
 Lung Antibodies  >102 publications with SSB and Lung
 Muscle Antibodies  >83 publications with SSB and Muscle
 Brain Antibodies  >74 publications with SSB and Brain
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