Alpha-2a Adrenergic Receptor (ADRA2A) Mouse Recombinant Protein

ADRA2A: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; synapse; receptor complex

Molecular Function: protein homodimerization activity; alpha-2C adrenergic receptor binding; adrenoceptor activity; protein heterodimerization activity; thioesterase binding; alpha2-adrenergic receptor activity; norepinephrine binding; epinephrine binding; protein kinase binding; heterotrimeric G-protein binding

Biological Process: positive regulation of cytokine production; fear response; negative regulation of calcium ion-dependent exocytosis; activation of protein kinase B; thermoception; female pregnancy; glucose homeostasis; positive regulation of vasodilation; positive regulation of membrane protein ectodomain proteolysis; negative regulation of insulin secretion; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; positive regulation of MAP kinase activity; negative regulation of cAMP biosynthetic process; negative regulation of lipid catabolic process; positive regulation of epidermal growth factor receptor activity; activation of protein kinase activity; DNA replication; acute inflammatory response; positive regulation of cell migration