Nociceptin Receptor (OPRL1) Human Recombinant Protein

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]

KOR-3: Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: neuron projection; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding; protein binding; nociceptin/orphanin-FQ receptor activity

Biological Process: synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; sensory perception; behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain