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3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 2 (HSD3B2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS954144

MBS954144 is a recombinant protein targeting Hsd3b2. Also known as Recombinant Mouse 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2), Recombinant Protein
Full Product Name
Recombinant Mouse 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2)
Product Gene Name
Hsd3b2 recombinant protein
Product Synonym Gene Name
Hsd3b2
Product Synonym Names
Recombinant 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2); 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II Including the followi
Sequence
PGWSCLVTGA GGFLGQRIIQ LLVQEEDLEE IRVLDKVFRP ETRKEFFNLE TSIKVTVLEG DILDTQYLRR ACQGISVVIH TAAIIDVTGV IPRQTILDVN LKGTQNLLEA CIQASVPAFI FSSSVDVAGP NSYKEIVLNG HEEECHESTW SDPYPYSKKM AEKAVLAANG SMLKNGGTLQ TCALRPMCIY GERSPLISNI IIMALKHKGI LRSFGKFNTA NPVYVGNVAW AHILAARGLR DPKKSPNIQG EFYYISDDTP HQSFDDISYT LSKEWGFCLD SSWSLPVPLL YWLAFLLETV SFLLSPIYRY IPPFNRHLVT LSGSTFTFSY KKAQRDLGYE PLVSWEEAKQ KTSEWIGTLV EQHRETLDTK SQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
41,923 Da
Sequence Positions
2-373
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 3; NC_000069.6 (98711107..98724543, complement). Location: 3 F2.2; 3 42.85 cM
3D Structure
ModBase 3D Structure for P26149
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Hsd3b2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Hsd3b2. It may not necessarily be applicable to this product.

NCBI GI #
162461559
NCBI GeneID
15493
NCBI Accession #
NP_694873.2
UniProt Primary Accession #
P26149
UniProt Secondary Accession #
Q8R0J6; B1ARN7
UniProt Related Accession #
P26149
GenBank Nucleotide #
NM_153193.3
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
NCBI Official Symbol
Hsd3b2
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II
Protein Family
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
UniProt Gene Name
Hsd3b2
UniProt Synonym Gene Names
3-beta-HSD II
UniProt Entry Name
3BHS2_MOUSE
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD II; 3 beta-hydroxysteroid dehydrogenase 2; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

UniProt Comments for Hsd3b2

HSD3B2: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.

Protein type: EC 1.1.1.145; Mitochondrial; Endoplasmic reticulum; Membrane protein, integral; Oxidoreductase; EC 5.3.3.1; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Isomerase

Cellular Component: membrane; mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space

Molecular Function: steroid delta-isomerase activity; 3-beta-hydroxy-delta5-steroid dehydrogenase activity; oxidoreductase activity; isomerase activity; catalytic activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Biological Process: metabolic process; steroid biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Hsd3b2 recombinant protein

 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 Glucocorticoid &amp; Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid &amp; Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamins A And D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamins A And D Pathway Diagram
 Mineralocorticoid Biosynthesis Pathway antibodies  Mineralocorticoid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram

Diseases associated with Hsd3b2 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >30 publications with Hsd3b2 and Neoplasms
 Hyperplasia Antibodies  >23 publications with Hsd3b2 and Hyperplasia
 Adrenal Hyperplasia, Congenital Antibodies  >22 publications with Hsd3b2 and Adrenal Hyperplasia, Congenital
 Prostatic Neoplasms Antibodies  >13 publications with Hsd3b2 and Prostatic Neoplasms
 Mental Disorders Antibodies  >6 publications with Hsd3b2 and Mental Disorders
 Polycystic Ovary Syndrome Antibodies  >5 publications with Hsd3b2 and Polycystic Ovary Syndrome
 Necrosis Antibodies  >4 publications with Hsd3b2 and Necrosis
 Hypertension Antibodies  >4 publications with Hsd3b2 and Hypertension
 Insulin Resistance Antibodies  >3 publications with Hsd3b2 and Insulin Resistance
 Hypospadias Antibodies  >3 publications with Hsd3b2 and Hypospadias

Organs/Tissues associated with Hsd3b2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >9 publications with Hsd3b2 and Liver
 Kidney Antibodies  >2 publications with Hsd3b2 and Kidney
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