Vang-Like Protein 2 (VANGL2) Rat Recombinant Protein

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Adaptor/scaffold

Cellular Component: basolateral plasma membrane; apical plasma membrane; plasma membrane; stress fiber; integral to membrane; intercellular junction; intracellular; ER to Golgi transport vesicle; lateral plasma membrane

Biological Process: positive regulation of JNK activity; convergent extension involved in axis elongation; wound healing; Wnt receptor signaling pathway, planar cell polarity pathway; somatic stem cell maintenance; inner ear receptor cell development; convergent extension involved in neural plate elongation; regulation of Wnt receptor signaling pathway; digestive tract morphogenesis; glomerulus development; Rho protein signal transduction; anterior/posterior pattern formation; establishment and/or maintenance of epithelial cell polarity; convergent extension involved in organogenesis; apical protein localization; inner ear receptor stereocilium organization and biogenesis; hair follicle development; sensory cilium biogenesis; regulation of actin cytoskeleton organization and biogenesis; neural tube closure; establishment of body hair orientation; somatic stem cell division; establishment of planar polarity; heart looping