Rat GATA4 Recombinant Protein – Cat# MBS954568

Transcription Factor GATA-4 (GATA4) Rat Recombinant Protein

Name: GATA4 Recombinant Protein; Transcription Factor GATA-4; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS954568
Price: 1210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS954568

This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in… More details

$1210 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Transcription factor GATA-4 (Gata4), Recombinant Protein

Full Product Name

Recombinant Rat Transcription factor GATA-4 (Gata4)

Product Gene Name

Gata4 recombinant protein

Sequence

MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG LSYLQGGGSG AASGATSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYSSSGGAAG AGLAGREQYG RPGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPAR HPNLDMFDDF SEGRECVNCG AMSTPLWRRD GTGHYLCNAC GLYHKMNGIN RPLIKPQRRL SASRRVGLSC ANCQTTTTTL WRRNAEGEPV CNACGLYMKL HGVPRPLAMR KEGIQTRKRK PKNLNKSKTP AGPPGESLPP SSGASSNSSN ATSSSSSSEE MRPIKTEPGL SSHYGHSSSM SQTFSTVSGH GSSIHPVLSA LKLSPQGYPS PVTQTSQASS KQDSWNSLVL ADSHGDIITA

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

44,597 Da

Sequence Positions

1-440, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P46152

Species

Rat

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Gata4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gata4 purchase

MBS954568 is a recombinant protein targeting Gata4. Also known as Recombinant Rat Transcription factor GATA-4 (Gata4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Gata4. It may not necessarily be applicable to this product.

NCBI GI #

25282465

NCBI GeneID

54254

NCBI Accession #

NP_653331.1

UniProt Primary Accession #

P46152

UniProt Related Accession #

P46152

GenBank Nucleotide #

NM_144730.1

NCBI Official Full Name

transcription factor GATA-4

NCBI Official Synonym Full Names

GATA binding protein 4

NCBI Official Symbol

Gata4

UniProt Protein Name

Transcription factor GATA-4

UniProt Synonym Protein Names

DNA-binding protein GATA-GT2; GATA-binding factor 4

Protein Family

GATA transcription factor

UniProt Gene Name

Gata4

NCBI Protein Information

transcription factor GATA-4

NCBI Summary for Gata4

plays a role in regulation of cardiac-myocyte specific gene expression; interacts with dHAND (HAND2) to activate transcription of several cardiac-specific genes [RGD, Feb 2006]

UniProt Comments for Gata4

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (). Promotes cardiac myocyte enlargement (). Required during testicular development (). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase ().

Research Articles on Gata4

1. Bioinformatics analysis and the dual-luciferase reporter assay demonstrated that miR-200c directly targeted the 3'-untranslated region of GATA-4, an important transcription factor for cardiomyocyte survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Gata4 recombinant protein

Reference Product	PubMed Publications
Nkx2-5 recombinant protein	>378 publications with Gata4 and Nkx2-5
Mef2c recombinant protein	>162 publications with Gata4 and Mef2c
Tbx5 recombinant protein	>147 publications with Gata4 and Tbx5
Zfpm2 recombinant protein	>51 publications with Gata4 and Zfpm2
Srf recombinant protein	>29 publications with Gata4 and Srf
Hand1 recombinant protein	>26 publications with Gata4 and Hand1
Mef2a recombinant protein	>11 publications with Gata4 and Mef2a
Nfatc4 recombinant protein	>10 publications with Gata4 and Nfatc4
Smad2 recombinant protein	>7 publications with Gata4 and Smad2
Gip recombinant protein	>3 publications with Gata4 and Gip

Pathways associated with Gata4 recombinant protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies	Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Thyroid Hormone Signaling Pathway antibodies	Thyroid Hormone Signaling Pathway Diagram
CGMP-PKG Signaling Pathway antibodies	CGMP-PKG Signaling Pathway Diagram
CGMP-PKG Signaling Pathway antibodies	CGMP-PKG Signaling Pathway Diagram

Diseases associated with Gata4 recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>456 publications with Gata4 and Heart Diseases
Cardiovascular Diseases Antibodies	>453 publications with Gata4 and Cardiovascular Diseases
Heart Defects, Congenital Antibodies	>199 publications with Gata4 and Heart Defects, Congenital
Hypertrophy Antibodies	>187 publications with Gata4 and Hypertrophy
Cardiomegaly Antibodies	>127 publications with Gata4 and Cardiomegaly
Myocardial Infarction Antibodies	>98 publications with Gata4 and Myocardial Infarction
Vascular Diseases Antibodies	>91 publications with Gata4 and Vascular Diseases
Fibrosis Antibodies	>57 publications with Gata4 and Fibrosis
Cardiomyopathies Antibodies	>47 publications with Gata4 and Cardiomyopathies
Hypertension Antibodies	>32 publications with Gata4 and Hypertension

Organs/Tissues associated with Gata4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>1064 publications with Gata4 and Heart
Embryonic Tissue Antibodies	>351 publications with Gata4 and Embryonic Tissue
Testis Antibodies	>144 publications with Gata4 and Testis
Ovary Antibodies	>90 publications with Gata4 and Ovary
Uncharacterized Tissue Antibodies	>1 publications with Gata4 and Uncharacterized Tissue