Mouse RBPJ Recombinant Protein – Cat# MBS954651

Recombining Binding Protein Suppressor of Hairless (RBPJ) Mouse Recombinant Protein

Name: RBPJ Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS954651
Price: 1330 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS954651

MBS954651 is a recombinant protein targeting Rbpj. Also known as Recombinant Mouse Recombining binding protein suppressor of hairless (Rbpj). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1330 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Recombining binding protein suppressor of hairless (Rbpj), Recombinant Protein

Full Product Name

Recombinant Mouse Recombining binding protein suppressor of hairless (Rbpj)

Product Gene Name

Rbpj recombinant protein

Sequence

MPSGFPQSPR TSPRARPKTR ITGALPMDYS EGLSAEERPA HAPSAGKFGE RPPPKRLTRE AMRNYLKERG DQTVLILHAK VAQKSYGNEK RFFCPPPCVY LMGSGWKKKK EQMERDGCSE QESQPCAFIG IGNSDQEMQQ LNLEGKNYCT AKTLYISDSD KRKHFMLSVK MFYGNSDDIG VFLSKRIKVI SKPSKKKQSL KNADLCIASG TKVALFNRLR SQTVSTRYLH VEGGNFHASS QQWGAFYIHL LDDDESEGEE FTVRDGYIHY GQTVKLVCSV TGMALPRLII RKVDKQTALL DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP KEQNKEMIND GASWTIISTD KAEYTFYEGM GPVLAPVTPV PVVESLQLNG GGDVAMLELT GQNFTPNLRV WFGDVEAETM YRCGESMLCV VPDISAFREG WRWVRQPVQV PVTLVRNDGV IYSTSLTFTY TPEPGPRPHC SAAGAILRAN SSQVPSNESN TNSEGNYTNA STNSTSVTSS TATVVS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

54,347 Da

Sequence Positions

1-526, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P31266

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Rbpj recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Rbpj. It may not necessarily be applicable to this product.

NCBI GI #

124286787

NCBI GeneID

19664

NCBI Accession #

NP_001074396.1

UniProt Primary Accession #

P31266

UniProt Secondary Accession #

Q80UN8; Q8C4Z3

UniProt Related Accession #

P31266

GenBank Nucleotide #

NM_001080927.2

NCBI Official Full Name

recombining binding protein suppressor of hairless isoform 2

NCBI Official Synonym Full Names

recombination signal binding protein for immunoglobulin kappa J region

NCBI Official Symbol

Rbpj

NCBI Official Synonym Symbols

CBF1; RBP-J; RBPjk; Igkjrb; Rbpsuh; Igkrsbp; AI843960; RBP-Jkappa; RBP-J kappa

UniProt Protein Name

Recombining binding protein suppressor of hairless

UniProt Synonym Protein Names

J kappa-recombination signal-binding protein; RBP-J kappa

Protein Family

Recombining binding protein suppressor of hairless

UniProt Gene Name

Rbpj

UniProt Synonym Gene Names

Igkjrb1; Igkrsbp; Rbpsuh

NCBI Protein Information

recombining binding protein suppressor of hairless

UniProt Comments for Rbpj

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) ().

Research Articles on Rbpj

1. Data (including data from studies in transgenic mice) suggest that signaling via Notch2 and Notch3 plays role in promoting cell differentiation and steroidogenesis in preovulatory granulosa cells; mechanism involves regulation of gene expression of Jag1 and Rbpj. (Notch2 = Notch2 receptor; Notch3 = Notch3 receptor; Jag1 = jagged-1 protein; Rbpj = recombining binding protein suppressor of hairless)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Rbpj recombinant protein

Reference Product	PubMed Publications
Notch1 recombinant protein	>110 publications with Rbpj and Notch1

Pathways associated with Rbpj recombinant protein

Products by Pathway	Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies	NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram

Diseases associated with Rbpj recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>63 publications with Rbpj and Neoplasms
Neoplasms, Experimental Antibodies	>17 publications with Rbpj and Neoplasms, Experimental
Neuroectodermal Tumors Antibodies	>10 publications with Rbpj and Neuroectodermal Tumors
Nervous System Diseases Antibodies	>8 publications with Rbpj and Nervous System Diseases
Gastrointestinal Diseases Antibodies	>7 publications with Rbpj and Gastrointestinal Diseases
Gastrointestinal Neoplasms Antibodies	>6 publications with Rbpj and Gastrointestinal Neoplasms
Adenocarcinoma Antibodies	>5 publications with Rbpj and Adenocarcinoma
Glioma Antibodies	>4 publications with Rbpj and Glioma
Necrosis Antibodies	>4 publications with Rbpj and Necrosis
Breast Neoplasms Antibodies	>4 publications with Rbpj and Breast Neoplasms

Organs/Tissues associated with Rbpj recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>27 publications with Rbpj and Embryonic Tissue
Bone Marrow Antibodies	>11 publications with Rbpj and Bone Marrow