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S-Arrestin (SAG) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS955104

Members of arrestinbeta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
S-arrestin (SAG), Recombinant Protein
Full Product Name
Recombinant Human S-arrestin (SAG)
Product Gene Name
SAG recombinant protein
Sequence
MAASGKTSKS EPNHVIFKKI SRDKSVTIYL GNRDYIDHVS QVQPVDGVVL VDPDLVKGKK VYVTLTCAFR YGQEDIDVIG LTFRRDLYFS RVQVYPPVGA ASTPTKLQES LLKKLGSNTY PFLLTFPDYL PCSVMLQPAP QDSGKSCGVD FEVKAFATDS TDAEEDKIPK KSSVRLLIRK VQHAPLEMGP QPRAEAAWQF FMSDKPLHLA VSLNKEIYFH GEPIPVTVTV TNNTEKTVKK IKAFVEQVAN VVLYSSDYYV KPVAMEEAQE KVPPNSTLTK TLTLLPLLAN NRERRGIALD GKIKHEDTNL ASSTIIKEGI DRTVLGILVS YQIKVKLTVS GFLGELTSSE VATEVPFRLM HPQPEDPAKE SYQDANLVFE EFARHNLKDA GEAEEGKRDK NDVDE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
47.1 kDa
Sequence Positions
1-405aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
181031
3D Structure
ModBase 3D Structure for P10523
Production Note
Special Offer: The Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for SAG recombinant protein

Neuroscience
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of SAG recombinant protein

Human SAG Recombinant Protein – Cat# MBS955104

Other Notes

Small volumes of SAG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SAG purchase

MBS955104 is a recombinant protein targeting SAG. Also known as Recombinant Human S-arrestin (SAG). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SAG. It may not necessarily be applicable to this product.

NCBI GI #
116008178
NCBI GeneID
6295
NCBI Accession #
NP_000532.2
UniProt Primary Accession #
P10523
UniProt Secondary Accession #
Q53SV3; Q99858; A0FDN6
UniProt Related Accession #
P10523
GenBank Nucleotide #
NM_000541.4
NCBI Official Full Name
S-arrestin
NCBI Official Synonym Full Names
S-antigen visual arrestin
NCBI Official Symbol
SAG
NCBI Official Synonym Symbols
RP47; S-AG
UniProt Protein Name
S-arrestin
UniProt Synonym Protein Names
48 kDa protein; Retinal S-antigen
Protein Family
S-arrestin
UniProt Gene Name
SAG
UniProt Synonym Gene Names
S-AG
NCBI Protein Information
S-arrestin

NCBI Summary for SAG

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]
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UniProt Comments for SAG

Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049).

Research Articles on SAG

1. This is the first dominant-acting mutation identified in SAG, a founder mutation possibly originating in Mexico several centuries ago. The phenotype is clearly adRP and is distinct from the previously reported phenotypes of recessive null mutations, that is, Oguchi disease and recessive RP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SAG recombinant protein

 Reference Product  PubMed Publications
 RHO recombinant protein  >8 publications with SAG and RHO
 GRK1 recombinant protein  >6 publications with SAG and GRK1
 SRC recombinant protein  >5 publications with SAG and SRC

Pathways associated with SAG recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of The Phototransduction Cascade Pathway antibodies  Activation Of The Phototransduction Cascade Pathway Diagram
 Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway antibodies  Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Phototransduction Cascade Pathway antibodies  The Phototransduction Cascade Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Visual Signal Transduction: Rods Pathway antibodies  Visual Signal Transduction: Rods Pathway Diagram

Diseases associated with SAG recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >92 publications with SAG and Cardiovascular Diseases
 Inflammation Antibodies  >90 publications with SAG and Inflammation
 Liver Diseases Antibodies  >63 publications with SAG and Liver Diseases
 Necrosis Antibodies  >60 publications with SAG and Necrosis
 Lung Diseases Antibodies  >42 publications with SAG and Lung Diseases
 Neoplasms, Experimental Antibodies  >31 publications with SAG and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >17 publications with SAG and Liver Neoplasms
 Uveitis Antibodies  >17 publications with SAG and Uveitis
 Oguchi disease Antibodies  >15 publications with SAG and Oguchi disease
 Kidney Diseases Antibodies  >14 publications with SAG and Kidney Diseases

Organs/Tissues associated with SAG recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >296 publications with SAG and Brain
 Muscle Antibodies  >136 publications with SAG and Muscle
 Eye Antibodies  >86 publications with SAG and Eye
 Connective Tissue Antibodies  >15 publications with SAG and Connective Tissue
 Ovary Antibodies  >7 publications with SAG and Ovary
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