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Galactocerebrosidase (GALC) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7053527

Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney… More details

$1285 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Galactocerebrosidase (Galc), Recombinant Protein
Full Product Name
Recombinant Mouse Galactocerebrosidase (Galc)
Product Gene Name
Product Synonym Gene Name
Galc
Product Synonym Names
Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase
Sequence
YVLDDSDGLG REFDGIGAVS GGGATSRLLV NYPEPYRSEI LDYLFKPNFG ASLHILKVEI GGDGQTTDGT EPSHMHYELD ENYFRGYEWW LMKEAKKRNP DIILMGLPWS FPGWLGKGFS WPYVNLQLTA YYVVRWILGA KHYHDLDIDY IGIWNERPFD ANYIKELRKM LDYQGLQRVR IIASDNLWEP ISSSLLLDQE LWKVVDVIGA HYPGTYTVWN AKMSGKKLWS SEDFSTINSN VGAGCWSRIL NQNYINGNMT STIAWNLVAS YYEELPYGRS GLMTAQEPWS GHYVVASPIW VSAHTTQFTQ PGWYYLKTVG HLEKGGSYVA LTDGLGNLTI IIETMSHQHS MCIRPYLPYY NVSHQLATFT LKGSLREIQE LQVWYTKLGT PQQRLHFKQL DTLWLLDGSG SFTLELEEDE IFTLTTLTTG RKGSYPPPPS SKPFPTNYKD DFNVEYPLFS EAPNFADQTG VFEYYMNNED REHRFTLRQV LNQRPITWAA DASSTISVIG DHHWTNMTVQ CDVYIETPRS GGVFIAGRVN KGGILIRSAT GVFFWIFANG SYRVTADLGG WITYASGHAD VTAKRWYTLT LGIKGYFAFG MLNGTILWKN VRVKYPGHGW AAIGTHTFEF AQFDNFRVEA AR
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
Molecular Weight
73.1 kDa
Sequence Positions
43-684aa; Full Length of Mature Protein
3D Structure
ModBase 3D Structure for P54818
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Galc recombinant protein

"Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease."Sakai N., Inui K., Tatsumi N., Fukushima H., Nishigaki T., Taniike M., Nishimoto J., Tsukamoto H., Yanagihara I., Ozono K., Okada S.J. Neurochem. 66:1118-1124(1996)

Other Notes

Small volumes of Galc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Galc purchase

MBS7053527 is a recombinant protein targeting Galc. Also known as Recombinant Mouse Galactocerebrosidase (Galc). Host: Cell Free Expression.

Additional Details

NCBI/Uniprot data below describe general gene information for Galc. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
galactocerebrosidase
NCBI Official Synonym Full Names
galactosylceramidase
NCBI Official Symbol
Galc
NCBI Official Synonym Symbols
twi; Gacy; AW212969; AW413532; twitcher; 2310068B06Rik; A930008M05Rik
UniProt Protein Name
Galactocerebrosidase
UniProt Synonym Protein Names
Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase
UniProt Gene Name
Galc
UniProt Synonym Gene Names
GALCERase
NCBI Protein Information
galactocerebrosidase

NCBI Summary for Galc

This gene encodes galactosylceramidase, the lysosomal hydryolase involved in the catabolism of galactosylceramide. Mutations in this gene result in slow growth, tremors and hind leg weakness, collectively termed as the 'twitcher' phenotype. In humans, deficiency of this gene product causes a lysosomal storage disorder known as Krabbe disease. [provided by RefSeq, Dec 2014]
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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