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Interleukin-6 Receptor Subunit Beta (IL6ST) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS955895

This protein is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The… More details

$1890 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-6 receptor subunit beta (Il6st), Recombinant Protein
Full Product Name
Recombinant Rat Interleukin-6 receptor subunit beta (Il6st), partial
Product Gene Name
Il6st recombinant protein
Sequence
QLVEPCGY IYPEFPVVQR GSNFTATCVL KEKCLQVYSV NATYIVWKTN HVAVPKEQVT VINRTASSVT FTDVVFQNVQ LTCNILSFGQ IEQNVYGITI LSGYPPDIPT NLSCIVNEGK NMLCQLDPGR ETYLETNYTL KSEWATEKFP DCRTKHGTSS CMMGYTPIYF VNIEVWVEAE NALGNVSSEP INFDPVDKVK PSPPHNLSVT NSEELSSILK LAWVNSGLDS ILRLKSDIQY RTKDASTWIQ VPLEDTVSPR TSFTVQDLKP FTEYVFRIRS IKENGKGYWS DWSEEASGTT YEDRPSKAPS FWYKVNANHP QEYRSARLIW KTLPLSEANG KILDYEVVLT QSKSVSQTYT VNGTELIVNL TNNRYVASLA ARNVVGKSPA TVLTIPGSHF KASHPVVDLK AFPKDNLLWV EWTPPSKPVN KYILEWCVLS ENSPCIPDWQ QEDGTVNRTH LRGSLLESKC YLITVTPVFP GGPGSPESMK AYLKQAAPSK GPTVRTKKVG KNEAVLEWDH LPVDVQNGFI RNYSISYRTS VGKEMVVRVD SSHTEYTLSS LSSDTLYMVH MAAYTEEGGK DGPEFTFTTL KFAQGEIE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
102,450 Da
Sequence Positions
23-618
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P40190
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Il6st recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il6st purchase

MBS955895 is a recombinant protein targeting Il6st. Also known as Recombinant Rat Interleukin-6 receptor subunit beta (Il6st), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Il6st. It may not necessarily be applicable to this product.

NCBI GI #
729835
NCBI GeneID
25205
NCBI Accession #
P40190.1
UniProt Primary Accession #
P40190
UniProt Related Accession #
P40190
NCBI Official Full Name
Interleukin-6 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 6 signal transducer
NCBI Official Symbol
Il6st
NCBI Official Synonym Symbols
Gp130; Ac1055; Il-6rb
UniProt Protein Name
Interleukin-6 receptor subunit beta
UniProt Synonym Protein Names
Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
Protein Family
Interleukin-6 receptor
UniProt Gene Name
Il6st
UniProt Synonym Gene Names
IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
NCBI Protein Information
interleukin-6 receptor subunit beta

NCBI Summary for Il6st

IL-6 signal transducing molecule [RGD, Feb 2006]

UniProt Comments for Il6st

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.
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Research Articles on Il6st

1. pulmonary exposure to MWCNT can manifest as a reduced epithelial barrier and activator of vascular gp130-associated transsignaling that may promote susceptibility to cardiovascular derangements

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Il6st recombinant protein

 Reference Product  PubMed Publications
 Lif recombinant protein  >242 publications with Il6st and Lif
 Il6 recombinant protein  >64 publications with Il6st and Il6
 Jak1 recombinant protein  >58 publications with Il6st and Jak1
 Jak2 recombinant protein  >50 publications with Il6st and Jak2
 Socs3 recombinant protein  >38 publications with Il6st and Socs3
 Ptpn11 recombinant protein  >32 publications with Il6st and Ptpn11
 Il6r recombinant protein  >30 publications with Il6st and Il6r
 Tyk2 recombinant protein  >21 publications with Il6st and Tyk2
 Ptpn6 recombinant protein  >14 publications with Il6st and Ptpn6
 Jak3 recombinant protein  >6 publications with Il6st and Jak3

Pathways associated with Il6st recombinant protein

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram
 Interleukin-6 Signaling Pathway antibodies  Interleukin-6 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with Il6st recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >164 publications with Il6st and Neoplasms
 Inflammation Antibodies  >99 publications with Il6st and Inflammation
 Cardiovascular Diseases Antibodies  >97 publications with Il6st and Cardiovascular Diseases
 Vascular Diseases Antibodies  >66 publications with Il6st and Vascular Diseases
 Multiple Myeloma Antibodies  >44 publications with Il6st and Multiple Myeloma
 Disease Models, Animal Antibodies  >42 publications with Il6st and Disease Models, Animal
 Necrosis Antibodies  >39 publications with Il6st and Necrosis
 Nervous System Diseases Antibodies  >39 publications with Il6st and Nervous System Diseases
 Liver Diseases Antibodies  >32 publications with Il6st and Liver Diseases
 Hypertrophy Antibodies  >30 publications with Il6st and Hypertrophy

Organs/Tissues associated with Il6st recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >96 publications with Il6st and Liver
 Brain Antibodies  >82 publications with Il6st and Brain
 Heart Antibodies  >74 publications with Il6st and Heart
 Muscle Antibodies  >71 publications with Il6st and Muscle
 Lung Antibodies  >37 publications with Il6st and Lung
 Embryonic Tissue Antibodies  >35 publications with Il6st and Embryonic Tissue
 Kidney Antibodies  >20 publications with Il6st and Kidney
 Spleen Antibodies  >19 publications with Il6st and Spleen
 Placenta Antibodies  >15 publications with Il6st and Placenta
 Colon Antibodies  >15 publications with Il6st and Colon
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