(Rhesus Macaque) C-C Chemokine Receptor Type 5 (CCR5) Macaca Mulatta Recombinant Protein

Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation

By similarity.

Subunit structure: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Post-translational modification: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4

By similarity.O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen

By similarity.Palmitoylation in the C-terminal is important for cell surface expression

By similarity.Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.