Beta-1 Adrenergic Receptor (ADRB1) Rat Recombinant Protein

ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: intracellular membrane-bound organelle; membrane; early endosome; cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; drug binding; norepinephrine binding; epinephrine binding; alpha-2A adrenergic receptor binding; Ras guanyl-nucleotide exchange factor activity; PDZ domain binding; beta1-adrenergic receptor activity

Biological Process: fear response; diet induced thermogenesis; wound healing; apoptosis; positive regulation of apoptosis; lipid homeostasis; positive regulation of systemic arterial blood pressure; sensory perception of pain; positive regulation of saliva secretion; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; positive regulation of adenylate cyclase activity; aging; negative regulation of multicellular organism growth; glycogen catabolic process; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of heart rate; regulation of calcium ion transport; memory; G-protein coupled receptor protein signaling pathway; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure