Human NF2 Recombinant Protein – Cat# MBS956203

Merlin (NF2) Human Recombinant Protein

Name: NF2 Recombinant Protein; Merlin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS956203
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS956203

Probable regulator of the HippoSWH (SavWtsHpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1… More details

$345 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Merlin (NF2), Recombinant Protein

Full Product Name

Recombinant Human Merlin (NF2)

Product Gene Name

NF2 recombinant protein

Sequence

MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

73.7 kDa

Sequence Positions

1-595aaaa; Full-Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

101000

3D Structure

ModBase 3D Structure for P35240

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for NF2 recombinant protein

Cancer

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for NF2 recombinant protein

"Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2." Rouleau G.A., Merel P., Lutchman M., Sanson M., Zucman J., Marineau C., Hoang-Xuan K., Demczuk S., Desmaze C., Plougastel B., Pulst S., Lenoir G., Bijlsma E., Fashold R., Dumanski J.P., de Jong P., Parry D., Eldrige R. Thomas G. Nature 363:515-521(1993)

Other Notes

Small volumes of NF2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NF2 purchase

MBS956203 is a recombinant protein targeting NF2. Also known as Recombinant Human Merlin (NF2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NF2. It may not necessarily be applicable to this product.

NCBI GI #

4557795

NCBI GeneID

4771

NCBI Accession #

NP_000259.1

UniProt Primary Accession #

P35240

UniProt Secondary Accession #

O95683; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3

UniProt Related Accession #

P35240

GenBank Nucleotide #

NM_000268.3

NCBI Official Full Name

merlin isoform 1

NCBI Official Synonym Full Names

neurofibromin 2

NCBI Official Symbol

NF2

NCBI Official Synonym Symbols

ACN; SCH; BANF

UniProt Protein Name

Merlin

UniProt Synonym Protein Names

Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin

Protein Family

Merlin

UniProt Gene Name

NF2

UniProt Synonym Gene Names

SCH

NCBI Protein Information

merlin

NCBI Summary for NF2

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]

UniProt Comments for NF2

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Research Articles on NF2

1. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NF2 recombinant protein

Reference Product	PubMed Publications
ERBB2 recombinant protein	>17 publications with NF2 and ERBB2
CD44 recombinant protein	>16 publications with NF2 and CD44
PAK1 recombinant protein	>9 publications with NF2 and PAK1
CTNNB1 recombinant protein	>8 publications with NF2 and CTNNB1
TSC1 recombinant protein	>4 publications with NF2 and TSC1
SCHIP1 recombinant protein	>3 publications with NF2 and SCHIP1
RALGDS recombinant protein	>2 publications with NF2 and RALGDS
PXN recombinant protein	>2 publications with NF2 and PXN
SDCBP recombinant protein	>1 publications with NF2 and SDCBP
SPTBN1 recombinant protein	>1 publications with NF2 and SPTBN1

Pathways associated with NF2 recombinant protein

Products by Pathway	Pathway Diagram
ErbB2/ErbB3 Signaling Events Pathway antibodies	ErbB2/ErbB3 Signaling Events Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram

Diseases associated with NF2 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>984 publications with NF2 and Neoplasms
Nervous System Diseases Antibodies	>866 publications with NF2 and Nervous System Diseases
Neurofibromatosis 2 Antibodies	>776 publications with NF2 and Neurofibromatosis 2
Meningioma Antibodies	>246 publications with NF2 and Meningioma
Schwannomatosis Antibodies	>74 publications with NF2 and Schwannomatosis
Mesothelioma Antibodies	>57 publications with NF2 and Mesothelioma
Meningioma, familial Antibodies	>54 publications with NF2 and Meningioma, familial
Eye Diseases Antibodies	>50 publications with NF2 and Eye Diseases
Skin Neoplasms Antibodies	>43 publications with NF2 and Skin Neoplasms
Carcinoma Antibodies	>38 publications with NF2 and Carcinoma

Organs/Tissues associated with NF2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>276 publications with NF2 and Brain
Skin Antibodies	>60 publications with NF2 and Skin
Eye Antibodies	>45 publications with NF2 and Eye
Bone Antibodies	>34 publications with NF2 and Bone
Lung Antibodies	>30 publications with NF2 and Lung
Muscle Antibodies	>29 publications with NF2 and Muscle
Vascular Antibodies	>26 publications with NF2 and Vascular
Liver Antibodies	>15 publications with NF2 and Liver
Kidney Antibodies	>15 publications with NF2 and Kidney
Embryonic Tissue Antibodies	>11 publications with NF2 and Embryonic Tissue