Rat NPR3 Recombinant Protein – Cat# MBS956481

Atrial Natriuretic Peptide Receptor 3 (NPR3) Rat Recombinant Protein

Name: NPR3 Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS956481
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS956481

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC,… More details

$335 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Atrial natriuretic peptide receptor 3 (Npr3), Recombinant Protein

Full Product Name

Recombinant Rat Atrial natriuretic peptide receptor 3 (Npr3), partial

Product Gene Name

Npr3 recombinant protein

Product Synonym Names

Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C

Sequence

EALAAQKIEV LVLLPRDDSY LFSLARVRPA IEYALRSVEG NGTGRKLLPP GTRFQVAYED SDCGNRALFS LVDRVAAARG AKPDLILGPV CEYAAAPVAR LASHWDLPML SAGALAAGFQ HKDTEYSHLT RVAPAYAKMG EMMLALFRHH HWSRAALLYS DDKLERNCYF TLEGVHEVFQ EEGLHTSAYN FDETKDLDLD DIVRYIQGSE RVVIMCASGD TIRRIMLAVH RHGMTSGDYA FFNIELFNSS SYGDGSWKRG DKHDFEAKQA YSSLQTVTLL RTAKPEFEKF SMEVKSSVEK QGLNEEDYVN MFVEGFHDAI LLYVLALHEV LRAGYSKKDG GKIIQQTWNR TFEGIAGQVS IDANGDRYGD FSVVAMTDTE AGTQEVIGDY FGKEGRFKMR SNVKYPWGSL KLRIDETRIV EHTNSSPCKS CGLEESA

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

64.9 kDa

Sequence Positions

41-477aa; Extracellular Domain

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P41740

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Npr3 recombinant protein

A single residue determines the distinct pharmacology of rat and human natriuretic peptide receptor-C.Engel A.M., Schoenfeld J.R., Lowe D.G.J. Biol. Chem. 269:17005-17008(1994) Gene expression of natriuretic peptide receptors in myocardial cells.Lin X., Hanze J., Heese F., Sodmann R., Lang R.E.Circ. Res. 77:750-758(1995)

Other Notes

Small volumes of Npr3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Npr3 purchase

MBS956481 is a recombinant protein targeting Npr3. Also known as Recombinant Rat Atrial natriuretic peptide receptor 3 (Npr3), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Npr3. It may not necessarily be applicable to this product.

NCBI GI #

6981282

NCBI GeneID

25339

NCBI Accession #

NP_037000.1

UniProt Primary Accession #

P41740

UniProt Secondary Accession #

Q64156

UniProt Related Accession #

P41740

GenBank Nucleotide #

NM_012868.1

NCBI Official Full Name

atrial natriuretic peptide receptor 3

NCBI Official Synonym Full Names

natriuretic peptide receptor 3

NCBI Official Symbol

Npr3

NCBI Official Synonym Symbols

NPRC; ANP-CR

UniProt Protein Name

Atrial natriuretic peptide receptor 3

UniProt Synonym Protein Names

Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C

Protein Family

Atrial natriuretic peptide receptor

UniProt Gene Name

Npr3

UniProt Synonym Gene Names

Npr-c; ANP-C; ANPR-C; NPR-C

UniProt Entry Name

ANPRC_RAT

NCBI Protein Information

atrial natriuretic peptide receptor 3

NCBI Summary for Npr3

receptor for natriuretic peptide; may play role in hypertension and neurotransmitter efflux [RGD, Feb 2006]

UniProt Comments for Npr3

ANP-C: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Belongs to the ANF receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: adenylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein homodimerization activity

Biological Process: cAMP-mediated signaling; cyclic nucleotide biosynthetic process; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of adenylate cyclase activity; negative regulation of smooth muscle cell proliferation; pancreatic juice secretion; phosphoinositide-mediated signaling; positive regulation of nitric-oxide synthase activity; regulation of blood pressure; regulation of osteoblast proliferation; skeletal development

Research Articles on Npr3

1. Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Npr3 recombinant protein

Reference Product	PubMed Publications
Nppb recombinant protein	>8 publications with Npr3 and Nppb
Nppc recombinant protein	>7 publications with Npr3 and Nppc
Nppa recombinant protein	>5 publications with Npr3 and Nppa

Diseases associated with Npr3 recombinant protein

Disease Name	Pubmed Publications
Hypertension Antibodies	>16 publications with Npr3 and Hypertension
Inflammation Antibodies	>3 publications with Npr3 and Inflammation
Hypertrophy Antibodies	>2 publications with Npr3 and Hypertrophy
Disease Models, Animal Antibodies	>2 publications with Npr3 and Disease Models, Animal
Fibrosis Antibodies	>2 publications with Npr3 and Fibrosis
Congenital Abnormalities Antibodies	>2 publications with Npr3 and Congenital Abnormalities
Atherosclerosis Antibodies	>2 publications with Npr3 and Atherosclerosis
Prenatal Injuries Antibodies	>2 publications with Npr3 and Prenatal Injuries
Prenatal Exposure Delayed Effects Antibodies	>2 publications with Npr3 and Prenatal Exposure Delayed Effects
Lung Diseases Antibodies	>1 publications with Npr3 and Lung Diseases

Organs/Tissues associated with Npr3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>18 publications with Npr3 and Brain