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Interleukin-1 Receptor Type 1 (IL1R1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS956542

MBS956542 is a recombinant protein targeting Il1r1. Also known as Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-1 receptor type 1 (Il1r1), Recombinant Protein
Full Product Name
Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1)
Product Gene Name
Il1r1 recombinant protein
Product Synonym Gene Name
Il1r1; Il-1r1; Il1ra
Product Synonym Names
Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD_antigen=; CD121aCleaved into the following 2 chains:; 1. Interleukin-1 recepto
Sequence
L EIDVCTEYPN QIVLFLSVNE IDIRKCPLTP NKMHGDTIIW YKNDSKTPIS ADRDSRIHQQ NEHLWFVPAK VEDSGYYYCI VRNSTYCLKT KVTVTVLEND PGLCYSTQAT FPQRLHIAGD GSLVCPYVSY FKDENNELPE VQWYKNCKPL LLDNVSFFGV KDKLLVRNVA EEHRGDYICR MSYTFRGKQY PVTRVIQFIT IDENKRDRPV ILSPRNETIE ADPGSMIQLI CNVTGQFSDL VYWKWNGSEI EWNDPFLAED YQFVEHPSTK RKYTLITTLN ISEVKSQFYR YPFICVVKNT NIFESAHVQL IYPVPDFK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
66,698 Da
Sequence Positions
20-338
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P13504
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Il1r1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Il1r1. It may not necessarily be applicable to this product.

NCBI GI #
6680417
NCBI GeneID
16177
NCBI Accession #
NP_032388.1
UniProt Primary Accession #
P13504
UniProt Related Accession #
P13504
GenBank Nucleotide #
NM_008362.2
NCBI Official Full Name
interleukin-1 receptor type 1 isoform 1
NCBI Official Synonym Full Names
interleukin 1 receptor, type I
NCBI Official Symbol
Il1r1
NCBI Official Synonym Symbols
IL-iR; CD121a; CD121b; IL-1R1; Il1r-1
UniProt Protein Name
Interleukin-1 receptor type 1
UniProt Synonym Protein Names
CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD_antigen: CD121aCleaved into the following 2 chains:Interleukin-1 receptor type 1, membrane form; mIL-1R1; mIL-1RI; Interleukin-1 receptor type 1, soluble form; sIL-1R1; sIL-1RI
Protein Family
Interleukin-1 receptor
UniProt Gene Name
Il1r1
UniProt Synonym Gene Names
Il-1r1; Il1ra; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI
UniProt Entry Name
IL1R1_MOUSE
NCBI Protein Information
interleukin-1 receptor type 1; p80; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha; IL-1 receptor alpha chain; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A

UniProt Comments for Il1r1

IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.

Protein type: Membrane protein, integral; EC 2.7.11.25; Receptor, cytokine

Cellular Component: extracellular space; protein complex; cell surface; membrane; axon; postsynaptic density; plasma membrane; integral to membrane; extracellular region; nucleus

Molecular Function: interleukin-1, Type I, activating receptor activity; ionotropic glutamate receptor binding; protein binding; signal transducer activity; protease binding; platelet-derived growth factor receptor binding; interleukin-1 receptor activity

Biological Process: response to radiation; cytokine and chemokine mediated signaling pathway; regulation of inflammatory response; heat acclimation; signal transduction
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Research Articles on Il1r1

1. Overexpression of Sprouty4 or pharmacological inhibition of ERK upregulated IL-1R1 expression in primary T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Il1r1 recombinant protein

 Reference Product  PubMed Publications
 IL1B recombinant protein  >23 publications with Il1r1 and IL1B
 IL1RN recombinant protein  >12 publications with Il1r1 and IL1RN
 IL1A recombinant protein  >11 publications with Il1r1 and IL1A
 MYD88 recombinant protein  >5 publications with Il1r1 and MYD88
 IL1RAP recombinant protein  >3 publications with Il1r1 and IL1RAP
 IRAK2 recombinant protein  >2 publications with Il1r1 and IRAK2
 TICAM2 recombinant protein  >1 publications with Il1r1 and TICAM2

Pathways associated with Il1r1 recombinant protein

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with Il1r1 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >45 publications with Il1r1 and Inflammation
 Necrosis Antibodies  >28 publications with Il1r1 and Necrosis
 Immune System Diseases Antibodies  >19 publications with Il1r1 and Immune System Diseases
 Nervous System Diseases Antibodies  >13 publications with Il1r1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >10 publications with Il1r1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >7 publications with Il1r1 and Lung Diseases
 Skin Diseases Antibodies  >7 publications with Il1r1 and Skin Diseases
 Disease Models, Animal Antibodies  >6 publications with Il1r1 and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with Il1r1 and Kidney Diseases
 Liver Diseases Antibodies  >4 publications with Il1r1 and Liver Diseases

Organs/Tissues associated with Il1r1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with Il1r1 and Blood
 Brain Antibodies  >9 publications with Il1r1 and Brain
 Vascular Antibodies  >6 publications with Il1r1 and Vascular
 Heart Antibodies  >5 publications with Il1r1 and Heart
 Liver Antibodies  >5 publications with Il1r1 and Liver
 Muscle Antibodies  >5 publications with Il1r1 and Muscle
 Uterus Antibodies  >5 publications with Il1r1 and Uterus
 Skin Antibodies  >5 publications with Il1r1 and Skin
 Lung Antibodies  >4 publications with Il1r1 and Lung
 Spleen Antibodies  >3 publications with Il1r1 and Spleen
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