Mouse TPT1 Recombinant Protein – Cat# MBS956588

Translationally-Controlled Tumor (TPT1) Mouse Recombinant Protein

Name: TPT1 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS956588
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS956588

MBS956588 is a recombinant protein targeting Tpt1. Also known as Recombinant Mouse Translationally-controlled tumor protein. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Involved in calcium binding and microtubule stabilization. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Translationally-controlled tumor (Tpt1), Recombinant Protein

Full Product Name

Recombinant Mouse Translationally-controlled tumor protein

Product Gene Name

Tpt1 recombinant protein

Product Synonym Gene Name

Trt

Product Synonym Names

21 kDa polypeptide; p21; p23

Sequence

MIIYRDLISH DELFSDIYKI REIADGLCLE VEGKMVSRTE GAIDDSLIGG NASAEGPEGE GTESTVVTGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSLK GKLEEQKPER VKPFMTGAAE QIKHILANFN NYQFFIGENM NPDGMVALLD YREDGVTPFM IFFKDGLEME KC

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

21.5 kDa

Sequence Positions

1-172aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P63028

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Tpt1 recombinant protein

Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells.Makrides S., Chitpatima S.T., Bandyopadhyay R., Brawerman G.Nucleic Acids Res. 16:2350-2350(1988) The growth-related protein P23 of the Ehrlich ascites tumor translational control, cloning and primary structure.Boehm H., Beendorf R., Gaestel M., Gross B., Nuernberg P., Kraft R., Otto A., Bielka H.Biochem. Int. 19:277-286(1989) Genomic organization and expression of mouse Tpt1 gene.Fiucci G., Lespagnol A., Stumptner-Cuvelette P., Beaucourt S., Duflaut D., Susini L., Amson R., Telerman A.Genomics 81:570-578(2003) Lubec G., Klug S., Yang J.W., Zigmond M.Submitted (JUL-2007) to UniProtKB

Other Notes

Small volumes of Tpt1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tpt1. It may not necessarily be applicable to this product.

NCBI GI #

6678437

NCBI GeneID

22070

NCBI Accession #

NP_033455.1

UniProt Primary Accession #

P63028

UniProt Secondary Accession #

P14701; Q3TMT0; Q3TWS8; Q3TWX0; Q3UAG7; Q569M9

UniProt Related Accession #

P63028

GenBank Nucleotide #

NM_009429.3

NCBI Official Full Name

translationally-controlled tumor protein

NCBI Official Synonym Full Names

tumor protein, translationally-controlled 1

NCBI Official Symbol

Tpt1

NCBI Official Synonym Symbols

Trt; p21; p23; TCTP

UniProt Protein Name

Translationally-controlled tumor protein

UniProt Synonym Protein Names

21 kDa polypeptide; p21; p23

Protein Family

Translationally-controlled tumor protein

UniProt Gene Name

Tpt1

UniProt Synonym Gene Names

Trt; TCTP

UniProt Entry Name

TCTP_MOUSE

NCBI Protein Information

translationally-controlled tumor protein

UniProt Comments for Tpt1

TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation.

Protein type: Microtubule-binding; Calcium-binding

Cellular Component: cytoplasm; extracellular space; multivesicular body; nucleoplasm; nucleus; tubulin complex

Molecular Function: calcium ion binding; protein binding; transcription factor binding

Biological Process: stem cell maintenance

Research Articles on Tpt1

1. TCTP over-expression-induced RhoA activation indicates that silencing of cellular TCTP may offer therapeutic approaches for the regulation of hypertension by inhibiting RhoA/Rho kinase pathway and modulating vascular contractility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Tpt1 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>8 publications with Tpt1 and Carcinoma
Cardiovascular Diseases Antibodies	>5 publications with Tpt1 and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>4 publications with Tpt1 and Neoplasms, Experimental
Liver Diseases Antibodies	>3 publications with Tpt1 and Liver Diseases
Liver Neoplasms Antibodies	>3 publications with Tpt1 and Liver Neoplasms
Breast Neoplasms Antibodies	>3 publications with Tpt1 and Breast Neoplasms
Carcinoma, Hepatocellular Antibodies	>3 publications with Tpt1 and Carcinoma, Hepatocellular
Cell Transformation, Neoplastic Antibodies	>2 publications with Tpt1 and Cell Transformation, Neoplastic
Lung Diseases Antibodies	>2 publications with Tpt1 and Lung Diseases
Asthma Antibodies	>1 publications with Tpt1 and Asthma

Organs/Tissues associated with Tpt1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Other Antibodies	>17 publications with Tpt1 and Other
Bone Antibodies	>4 publications with Tpt1 and Bone
Heart Antibodies	>4 publications with Tpt1 and Heart
Liver Antibodies	>4 publications with Tpt1 and Liver
Skin Antibodies	>4 publications with Tpt1 and Skin
Lung Antibodies	>3 publications with Tpt1 and Lung
Brain Antibodies	>3 publications with Tpt1 and Brain
Blood Antibodies	>3 publications with Tpt1 and Blood
Muscle Antibodies	>2 publications with Tpt1 and Muscle
Pancreas Antibodies	>2 publications with Tpt1 and Pancreas