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Histidine-Rich Glycoprotein (HRG) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS956729

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette… More details

$1135 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Histidine-rich glycoprotein (HRG), Recombinant Protein
Full Product Name
Recombinant Bovine Histidine-rich glycoprotein (HRG)
Product Gene Name
HRG recombinant protein
Sequence
AVNPTGCDAV EPVAVRALDL INKGRDGYLF QLLRVADAHL DKVESIAVYY LVESDCPVLS RKHWDDCELN VTVIGQCKLA GPEDLSVNDF NCTTSSVSSA LTNMRARGGE GTSYFLDFSV RNCSSHHFPR HHIFGFCRAD LFYDVEASDL ETPKDIVTNC EVFHRRFSAV QHHLGRPFHS GEHEHSPAGR PPFKPSGSKD HGHPHESYNF RCPPPLEHKN HSDSPPFQAR APLPFPPPGL RCPHPPFGTK GNHRPPHDHS SDEHHPHGHH PHGHHPHGHH PHGHHPPDND FYDHGPCDPP PHRPPPRHSK ERGPGKGHFR FHWRPTGYIH RLPSLKKGEV LPLPEANFPS FSLPNHNNPL QPEIQAFPQS ASESCPGTFN IKFLHISKFF AYTLPK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
44,471 Da
Sequence Positions
1-396, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P33433
Species
Bovine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HRG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HRG purchase

MBS956729 is a recombinant protein targeting HRG. Also known as Recombinant Bovine Histidine-rich glycoprotein (HRG). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for HRG. It may not necessarily be applicable to this product.

NCBI GI #
23397341
NCBI GeneID
280820
NCBI Accession #
P33433.1
UniProt Primary Accession #
P33433
UniProt Related Accession #
P33433
NCBI Official Full Name
Histidine-rich glycoprotein
NCBI Official Synonym Full Names
histidine rich glycoprotein
NCBI Official Symbol
HRG
NCBI Official Synonym Symbols
HPRG
UniProt Protein Name
Histidine-rich glycoprotein
UniProt Synonym Protein Names
Histidine-proline-rich glycoprotein; HPRG
UniProt Gene Name
HRG
UniProt Synonym Gene Names
HPRG
NCBI Protein Information
histidine-rich glycoprotein

UniProt Comments for HRG

Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 ().
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Research Articles on HRG

1. the anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HRG recombinant protein

 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with HRG and FLNA

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