Human TNFAIP8 Recombinant Protein – Cat# MBS956964

Tumor Necrosis Factor Alpha-Induced Protein 8 (TNFAIP8) Human Recombinant Protein

Name: TNFAIP8 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS956964
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS956964

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tumor necrosis factor alpha-induced protein 8 (TNFAIP8), Recombinant Protein

Full Product Name

Recombinant Human Tumor necrosis factor alpha-induced protein 8

Product Gene Name

TNFAIP8 recombinant protein

Product Synonym Names

Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDEDSCC-S2TNF-induced protein GG2-1

Sequence

HSEAEESKEV ATDVFNSKNL AVQAQKKILG KMVSKSIATT LIDDTSSEVL DELYRVTREY TQNKKEAEKI IKNLIKTVIK LAILYRNNQF NQDELALMEK FKKKVHQLAM TVVSFHQVDY TFDRNVLSRL LNECREMLHQ IIQRHLTAKS HGRVNNVFDH FSDCEFLAAL YNPFGNFKPH LQKLCDGINK MLDEENI

Host

E Coli

Form/Format

Liquid containing glycerol

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

49.9 kDa

Sequence Positions

2-198aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

612111

3D Structure

ModBase 3D Structure for O95379

Product Categories/Family for TNFAIP8 recombinant protein

Apoptosis

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for TNFAIP8 recombinant protein

Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.Blood 93:3418-3431(1999)

Other Notes

Small volumes of TNFAIP8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFAIP8 purchase

MBS956964 is a recombinant protein targeting TNFAIP8. Also known as Recombinant Human Tumor necrosis factor alpha-induced protein 8. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFAIP8. It may not necessarily be applicable to this product.

NCBI GI #

117676370

NCBI GeneID

25816

NCBI Accession #

NP_001071122.1

UniProt Primary Accession #

O95379

UniProt Secondary Accession #

Q9P1Q1; Q9UER5; Q9UP47; B3KMH1; B3KMI2; B7Z713

UniProt Related Accession #

O95379

GenBank Nucleotide #

NM_001077654.2

NCBI Official Full Name

tumor necrosis factor alpha-induced protein 8 isoform b

NCBI Official Synonym Full Names

TNF alpha induced protein 8

NCBI Official Symbol

TNFAIP8

NCBI Official Synonym Symbols

NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13

UniProt Protein Name

Tumor necrosis factor alpha-induced protein 8

UniProt Synonym Protein Names

Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1

Protein Family

Tumor necrosis factor alpha-induced protein

UniProt Gene Name

TNFAIP8

UniProt Synonym Gene Names

TNF alpha-induced protein 8; NDED

UniProt Entry Name

TFIP8_HUMAN

NCBI Protein Information

tumor necrosis factor alpha-induced protein 8

UniProt Comments for TNFAIP8

TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: cytoplasm

Molecular Function: caspase inhibitor activity; protein binding

Biological Process: defense response to Gram-positive bacterium; interleukin-1 beta production; negative regulation of apoptosis; negative regulation of caspase activity

Research Articles on TNFAIP8

1. Our data suggest that TNFAIP8 overexpression may contribute to lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFAIP8 recombinant protein

Reference Product	PubMed Publications
CASP8 recombinant protein	>1 publications with TNFAIP8 and CASP8
NR2F1 recombinant protein	>1 publications with TNFAIP8 and NR2F1

Diseases associated with TNFAIP8 recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>31 publications with TNFAIP8 and Necrosis
Inflammation Antibodies	>10 publications with TNFAIP8 and Inflammation
Neoplasm Metastasis Antibodies	>6 publications with TNFAIP8 and Neoplasm Metastasis
Disease Models, Animal Antibodies	>5 publications with TNFAIP8 and Disease Models, Animal
Adenocarcinoma Antibodies	>3 publications with TNFAIP8 and Adenocarcinoma
Lung Neoplasms Antibodies	>2 publications with TNFAIP8 and Lung Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with TNFAIP8 and Carcinoma, Hepatocellular
Cardiovascular Diseases Antibodies	>2 publications with TNFAIP8 and Cardiovascular Diseases
Weight Loss Antibodies	>2 publications with TNFAIP8 and Weight Loss
Liver Diseases Antibodies	>2 publications with TNFAIP8 and Liver Diseases

Organs/Tissues associated with TNFAIP8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2 publications with TNFAIP8 and Lung