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Nuclear Receptor Subfamily 2 Group F Member 6 (NR2F6) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS957029

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Nuclear receptor subfamily 2 group F member 6 (NR2F6), Recombinant Protein
Full Product Name
Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6)
Product Gene Name
NR2F6 recombinant protein
Product Synonym Names
V-erbA-related protein 2; EAR-2
Sequence
MAMVTGGWGG PGGDTNGVDK AGGYPRAAED DSASPPGAAS DAEPGDEERP GLQVDCVVCG DKSSGKHYGV FTCEGCKSFF KRSIRRNLSY TCRSNRDCQI DQHHRNQCQY CRLKKCFRVG MRKEAVQRGR IPHSLPGAVA ASSGSPPGSA LAAVASGGDL FPGQPVSELI AQLLRAEPYP AAAGRFGAGG GAAGAVLGID NVCELAARLL FSTVEWARHA PFFPELPVAD QVALLRLSWS ELFVLNAAQA ALPLHTAPLL AAAGLHAAPM AAERAVAFMD QVRAFQEQVD KLGRLQVDSA EYGCLKAIAL FTPDACGLSD PAHVESLQEK AQVALTEYVR AQYPSQPQRF GRLLLRLPAL RAVPASLISQ LFFMRLVGKT PIETLIRDML LSGSTFNWPY GSGQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
47 kDa
Sequence Positions
1-404aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
132880
3D Structure
ModBase 3D Structure for P10588
Species
Homo sapiens (Human)
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for NR2F6 recombinant protein

Epigenetics and Nuclear Signaling
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of NR2F6 recombinant protein

Human NR2F6 Recombinant Protein – Cat# MBS957029

Product References and Citations for NR2F6 recombinant protein

"Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other." Miyajima N., Kadowaki Y., Fukushige S., Shimizu S., Semba K., Yamanashi Y., Matsubara K., Toyoshima K., Yamamoto T. Nucleic Acids Res. 16:11057-11074(1988)

Other Notes

Small volumes of NR2F6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR2F6 purchase

MBS957029 is a recombinant protein targeting NR2F6. Also known as Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2F6. It may not necessarily be applicable to this product.

NCBI GI #
20070199
NCBI GeneID
2063
NCBI Accession #
NP_005225.2
UniProt Primary Accession #
P10588
UniProt Secondary Accession #
Q5XGA0; Q6P586; Q9BUE8; B2RC68
UniProt Related Accession #
P10588
GenBank Nucleotide #
NM_005234.3
NCBI Official Full Name
nuclear receptor subfamily 2 group F member 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group F member 6
NCBI Official Symbol
NR2F6
NCBI Official Synonym Symbols
EAR2; EAR-2; ERBAL2
UniProt Protein Name
Nuclear receptor subfamily 2 group F member 6
UniProt Synonym Protein Names
V-erbA-related protein 2; EAR-2
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR2F6
UniProt Synonym Gene Names
EAR2; ERBAL2; EAR-2
UniProt Entry Name
NR2F6_HUMAN
NCBI Protein Information
nuclear receptor subfamily 2 group F member 6

UniProt Comments for NR2F6

EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; zinc ion binding

Biological Process: detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod; gene expression; intracellular receptor-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neuron development; signal transduction; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter
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Research Articles on NR2F6

1. EAR2/NR2F6 and related NRs such as the COUPTFs, TLX and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NR2F6 recombinant protein

 Reference Product  PubMed Publications
 NR4A1 recombinant protein  >4 publications with NR2F6 and NR4A1
 NR4A2 recombinant protein  >2 publications with NR2F6 and NR4A2
 NR2C1 recombinant protein  >1 publications with NR2F6 and NR2C1
 RASD1 recombinant protein  >1 publications with NR2F6 and RASD1

Pathways associated with NR2F6 recombinant protein

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with NR2F6 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with NR2F6 and Inflammation
 Hypertension Antibodies  >2 publications with NR2F6 and Hypertension
 Breast Neoplasms Antibodies  >2 publications with NR2F6 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with NR2F6 and Cardiovascular Diseases
 Memory Disorders Antibodies  >1 publications with NR2F6 and Memory Disorders
 Brain Diseases Antibodies  >1 publications with NR2F6 and Brain Diseases
 Kidney Diseases Antibodies  >1 publications with NR2F6 and Kidney Diseases
 Hyperplasia Antibodies  >1 publications with NR2F6 and Hyperplasia

Organs/Tissues associated with NR2F6 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with NR2F6 and Brain
 Liver Antibodies  >4 publications with NR2F6 and Liver
 Bone Antibodies  >3 publications with NR2F6 and Bone
 Prostate Antibodies  >2 publications with NR2F6 and Prostate
 Kidney Antibodies  >2 publications with NR2F6 and Kidney
 Nerve Antibodies  >2 publications with NR2F6 and Nerve
 Bone Marrow Antibodies  >1 publications with NR2F6 and Bone Marrow
 Placenta Antibodies  >1 publications with NR2F6 and Placenta
 Testis Antibodies  >1 publications with NR2F6 and Testis
 Muscle Antibodies  >1 publications with NR2F6 and Muscle
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