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Calreticulin (CALR) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS957196

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are… More details

$440 / 0.02 mg (Yeast) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Calreticulin (Calr), Recombinant Protein
Full Product Name
Recombinant Mouse Calreticulin (Calr)
Product Gene Name
Calr recombinant protein
Product Synonym Names
CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP
Sequence
DPAIYFKEQF LDGDAWTNRW VESKHKSDFG KFVLSSGKFY GDLEKDKGLQ TSQDARFYAL SAKFEPFSNK GQTLVVQFTV KHEQNIDCGG GYVKLFPSGL DQKDMHGDSE YNIMFGPDIC GPGTKKVHVI FNYKGKNVLI NKDIRCKDDE FTHLYTLIVR PDNTYEVKID NSQVESGSLE DDWDFLPPKK IKDPDAAKPE DWDERAKIDD PTDSKPEDWD KPEHIPDPDA KKPEDWDEEM DGEWEPPVIQ NPEYKGEWKP RQIDNPDYKG TWIHPEIDNP EYSPDANIYA YDSFAVLGLD LWQVKSGTIF DNFLITNDEA YAEEFGNETW GVTKAAEKQM KDKQDEEQRL KEEEEDKKRK EEEEAEDKED DDDRDEDEDE EDEKEEDEEE SPGQAKDEL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
48.3 kDa
Sequence Positions
18-416aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P14211
Production Note
Special Offer: The E Coli, Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Coli, Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli, Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli, Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Calr recombinant protein

Mouse CALR Recombinant Protein – Cat# MBS957196

Product References and Citations for Calr recombinant protein

Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP) , a major calcium binding ER/SR protein.Smith M.J., Koch G.L.E.EMBO J. 8:3581-3586(1989) Determination of the sequence of an expressible cDNA clone encoding ERp60/calregulin by the use of a novel nested set method.Mazzarella R.A., Gold P., Cunningham M., Green M.Gene 120:217-225(1992) Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.Merrick B.A., Patterson R.M., Wichter L.L., He C., Selkirk J.K.Electrophoresis 15:735-745(1994) Lubec G., Kang S.U., Sunyer B., Chen W.-Q.Submitted (JAN-2009) to UniProtKB The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.Dupuis M., Schaerer E., Krause K.-H., Tschopp J.J. Exp. Med. 177:1-7(1993) Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.Timchenko L.T., Salisbury E., Wang G.-L., Nguyen H., Albrecht J.H., Hershey J.W., Timchenko N.A.J. Biol. Chem. 281:32806-32819(2006) Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.Kozlov G., Bastos-Aristizabal S., Maattanen P., Rosenauer A., Zheng F., Killikelly A., Trempe J.F., Thomas D.Y., Gehring K.J. Biol. Chem. 285:35551-35557(2010) A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome.Bhattacharya R., Devi M.S., Dhople V.M., Jesudasan R.A.BMC Cell Biol. 14:50-50(2013) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013) Structural basis of carbohydrate recognition by calreticulin.Kozlov G., Pocanschi C.L., Rosenauer A., Bastos-Aristizabal S., Gorelik A., Williams D.B., Gehring K.J. Biol. Chem. 285:38612-38620(2010) Structural and functional relationships between the lectin and arm domains of calreticulin.Pocanschi C.L., Kozlov G., Brockmeier U., Brockmeier A., Williams D.B., Gehring K.J. Biol. Chem. 286:27266-27277(2011)

Other Notes

Small volumes of Calr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Calr purchase

MBS957196 is a recombinant protein targeting Calr. Also known as Recombinant Mouse Calreticulin (Calr). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Calr. It may not necessarily be applicable to this product.

NCBI GI #
6680836
NCBI GeneID
12317
NCBI Accession #
NP_031617.1
UniProt Primary Accession #
P14211
UniProt Secondary Accession #
Q3TVD2
UniProt Related Accession #
P14211
GenBank Nucleotide #
NM_007591.3
NCBI Official Full Name
calreticulin
NCBI Official Synonym Full Names
calreticulin
NCBI Official Symbol
Calr
NCBI Official Synonym Symbols
CRT; Calregulin
UniProt Protein Name
Calreticulin
UniProt Synonym Protein Names
CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP
UniProt Gene Name
Calr
UniProt Synonym Gene Names
ERp60
UniProt Entry Name
CALR_MOUSE
NCBI Protein Information
calreticulin

UniProt Comments for Calr

Calreticulin: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57. Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Belongs to the calreticulin family.

Protein type: Motility/polarity/chemotaxis; Calcium-binding; Secreted; Nuclear receptor co-regulator; Secreted, signal peptide

Cellular Component: acrosome; cell surface; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; external side of plasma membrane; extracellular matrix; extracellular space; focal adhesion; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus; perinuclear region of cytoplasm; polysome; protein complex; sarcoplasmic reticulum; smooth endoplasmic reticulum

Molecular Function: androgen receptor binding; calcium ion binding; carbohydrate binding; glycoprotein binding; hormone binding; integrin binding; iron ion binding; metal ion binding; mRNA binding; peptide binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: cell cycle arrest; cortical actin cytoskeleton organization and biogenesis; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of steroid hormone receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translation; peptide antigen assembly with MHC class I protein complex; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of phagocytosis; protein export from nucleus; protein folding; protein stabilization; regulation of meiosis
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Research Articles on Calr

1. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin-substrate interactions and as key determinants of PLC dynamics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Calr recombinant protein

 Reference Product  PubMed Publications
 Pdia3 recombinant protein  >5 publications with Calr and Pdia3
 Pdia4 recombinant protein  >2 publications with Calr and Pdia4
 Hyou1 recombinant protein  >2 publications with Calr and Hyou1
 Hsp90b1 recombinant protein  >2 publications with Calr and Hsp90b1
 P4hb recombinant protein  >1 publications with Calr and P4hb

Diseases associated with Calr recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with Calr and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >13 publications with Calr and Neoplasms, Experimental
 Fibrosis Antibodies  >9 publications with Calr and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >7 publications with Calr and Cell Transformation, Neoplastic
 Inflammation Antibodies  >6 publications with Calr and Inflammation
 Disease Models, Animal Antibodies  >5 publications with Calr and Disease Models, Animal
 Hyperplasia Antibodies  >4 publications with Calr and Hyperplasia
 Liver Diseases Antibodies  >4 publications with Calr and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with Calr and Liver Neoplasms
 Hepatomegaly Antibodies  >3 publications with Calr and Hepatomegaly

Organs/Tissues associated with Calr recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with Calr and Blood
 Bone Antibodies  >49 publications with Calr and Bone
 Bone Marrow Antibodies  >47 publications with Calr and Bone Marrow
 Brain Antibodies  >29 publications with Calr and Brain
 Intestine Antibodies  >15 publications with Calr and Intestine
 Lung Antibodies  >8 publications with Calr and Lung
 Liver Antibodies  >7 publications with Calr and Liver
 Kidney Antibodies  >4 publications with Calr and Kidney
 Eye Antibodies  >4 publications with Calr and Eye
 Muscle Antibodies  >4 publications with Calr and Muscle
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