Rat ABCG8 Recombinant Protein – Cat# MBS957499

ATP-Binding Cassette Sub-Family G Member 8 (ABCG8) Rat Recombinant Protein

Name: ABCG8 Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS957499
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS957499

MBS957499 is a recombinant protein targeting Abcg8. Also known as Recombinant Rat ATP-binding cassette sub-family G member 8 (Abcg8). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Abcg8 More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATP-binding cassette sub-family G member 8 (Abcg8), Recombinant Protein

Full Product Name

Recombinant Rat ATP-binding cassette sub-family G member 8 (Abcg8)

Product Gene Name

Abcg8 recombinant protein

Product Synonym Gene Name

Recombinant ATP-binding cassette sub-family G member 8 (Abcg8); ATP-binding cassette sub-family G member 8; Sterolin-2

Sequence

MAEKTKEETQ LWNGTVLQDA SSLQDSVFSS ESDNSLYFTY SGQSNTLEVR DLTYQGGTCL RSWGQEDPHM SLGLSESVDM ASQVPWFEQL AQFKLPWRSR GSQDSWDLGI RNLSFKVRSG QMLAIIGSAG CGRATLLDVI TGRDHGGKMK SGQIWINGQP STPQLIQKCV AHVRQQDQLL PNLTVRETLT FIAQMRLPKT FSQAQRDKRV EDVIAELRLR QCANTRVGNT YVRGVSGGER RRVSIGVQLL WNPGILILDE PTSGLDSFTA HNLVRTLSRL AKGNRLVLIS LHQPRSDIFR LFDLVLLMTS GTPIYLGVAQ HMVQYFTSIG YPCPRYSNPA DFYVDLTSID RRSKEQEVAT MEKARLLAAL FLEKVQGFDD FLWKAEAKSL DTGTYAVSQT LTQDTNCGTA AELPGMIQQF TTLIRRQISN DFRDLPTLFI HGAEACLMSL IIGFLYYGHA DKPLSFMDMA ALLFMIGALI PFNVILDVVS KCHSERSLLY YELEDGLYTA GPYFFAKVLG ELPEHCAYVI IYGMPIYWLT NLRPGPELFL LHFMLLWLVV FCCRTMALAA SAMLPTFHMS SFCCNALYNS FYLTAGFMIN LNNLWIVPAW ISKMSFLRWC FSGLMQIQFN GHIYTTQIGN LTFSVPGDAM VTAMDLNSHP LYAIYLIVIG ISCGFLSLYY LSLKFIKQKS IQDW

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

78,236 Da

Sequence Positions

1-694

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 6; NC_005105.3 (7897005..7916593). Location: 6q12

3D Structure

ModBase 3D Structure for P58428

Species

Rattus norvegicus (Rat)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Abcg8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Abcg8. It may not necessarily be applicable to this product.

NCBI GI #

26080338

NCBI GeneID

155192

NCBI Accession #

NP_569098.2

UniProt Primary Accession #

P58428

UniProt Secondary Accession #

Q8CIQ5; Q923R7

UniProt Related Accession #

P58428

GenBank Nucleotide #

NM_130414.2

NCBI Official Full Name

ATP-binding cassette sub-family G member 8

NCBI Official Synonym Full Names

ATP-binding cassette, subfamily G (WHITE), member 8

NCBI Official Symbol

Abcg8

UniProt Protein Name

ATP-binding cassette sub-family G member 8

UniProt Synonym Protein Names

Sterolin-2

Protein Family

ABC transporter G family

UniProt Gene Name

Abcg8

UniProt Entry Name

ABCG8_RAT

NCBI Protein Information

ATP-binding cassette sub-family G member 8; sterolin 2; sterolin-2; ATP-binding cassette, sub-family G (WHITE), member 8

NCBI Summary for Abcg8

ATP-binding cassette (ABC) transporter that regulates sterol absorption and excretion; mutation causes sitosterolemia [RGD, Feb 2006]

UniProt Comments for Abcg8

Function: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Subunit structure: May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein

Probable.

Tissue specificity: Highest expression in liver, with lower levels in small intestine and colon. Ref.3

Sequence similarities: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]Contains 1 ABC transmembrane type-2 domain.Contains 1 ABC transporter domain.

Caution: Seems to have a defective ATP-binding region.

Research Articles on Abcg8

1. Data reveal marked utilization of an Abcg5/Abcg8-independent mechanism for basal biliary cholesterol secretion in rats during lactation, but a dependence on Abcg5/g8 for maximal biliary cholesterol secretion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Abcg8 recombinant protein

Products by Pathway	Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Retinol Metabolism Pathway antibodies	Retinol Metabolism Pathway Diagram

Diseases associated with Abcg8 recombinant protein

Disease Name	Pubmed Publications
Sitosterolemia Antibodies	>60 publications with Abcg8 and Sitosterolemia
Dyslipidemias Antibodies	>55 publications with Abcg8 and Dyslipidemias
Hyperlipidemias Antibodies	>52 publications with Abcg8 and Hyperlipidemias
Hypercholesterolemia Antibodies	>50 publications with Abcg8 and Hypercholesterolemia
Atherosclerosis Antibodies	>49 publications with Abcg8 and Atherosclerosis
Cardiovascular Diseases Antibodies	>41 publications with Abcg8 and Cardiovascular Diseases
Liver Diseases Antibodies	>38 publications with Abcg8 and Liver Diseases
Gallstones Antibodies	>34 publications with Abcg8 and Gallstones
Cholelithiasis Antibodies	>30 publications with Abcg8 and Cholelithiasis
Fatty Liver Antibodies	>26 publications with Abcg8 and Fatty Liver

Organs/Tissues associated with Abcg8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>2 publications with Abcg8 and Mixed