Synaptotagmin-1 (SYT1) Rat Recombinant Protein

SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Protein type: Vesicle; Membrane protein, integral; Calcium-binding

Cellular Component: neuron projection; synaptic vesicle membrane; cell; integral to membrane; terminal button; intracellular organelle; excitatory synapse; secretory granule; SNARE complex; presynaptic membrane; synaptic vesicle; cytoplasm; plasma membrane; cell junction

Molecular Function: protein C-terminus binding; identical protein binding; clathrin binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding; calcium-dependent protein binding; calmodulin binding; phosphatidylinositol-4,5-bisphosphate binding; SNARE binding; protein binding; syntaxin binding; low-density lipoprotein receptor binding; phosphatidylserine binding; syntaxin-1 binding; phospholipid binding

Biological Process: positive regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; regulation of synaptic transmission, glutamatergic; vesicle docking; neurotransmitter secretion; positive regulation of vesicle fusion; detection of calcium ion; response to calcium ion; regulation of calcium ion-dependent exocytosis; positive regulation of synaptic transmission; calcium ion-dependent exocytosis