Rat EFNA1 Recombinant Protein – Cat# MBS958041

Ephrin-A1 (EFNA1) Rat Recombinant Protein

Name: EFNA1 Recombinant Protein; Ephrin-A1; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS958041
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS958041

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ephrin-A1 (Efna1), Recombinant Protein

Full Product Name

Recombinant Rat Ephrin-A1

Product Gene Name

Efna1 recombinant protein

Product Synonym Names

EPH-related receptor tyrosine kinase ligand 1; LERK-1; Immediate early response protein B61

Sequence

ADRHIVFWNS SNPKFREEDY TVHVQLNDYL DIICPHYEDD SVADAAMERY TLYMVEHQEY VTCEPQSKDQ VRWKCNQPSA KHGPEKLSEK FQRFTPFTLG KEFKEGHSYY YISKPIYHQE TQCLKLKVTV NGKITHSPHA HANPQEKRLQ ADDPEVQVLH SIGHS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

21.4 kDa

Sequence Positions

18-182. Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P97553

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Efna1 recombinant protein

Molecular cloning and expression of rat and mouse B61 gene implications on organogenesis.Takahashi H., Ikeda T.Oncogene 11:879-883(1995)

Other Notes

Small volumes of Efna1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Efna1 purchase

MBS958041 is a recombinant protein targeting Efna1. Also known as Recombinant Rat Ephrin-A1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Efna1. It may not necessarily be applicable to this product.

NCBI GI #

61889105

NCBI GeneID

94268

NCBI Accession #

NP_446051.2

UniProt Primary Accession #

P97553

UniProt Secondary Accession #

Q6NS29

UniProt Related Accession #

P97553

GenBank Nucleotide #

NM_053599.2

NCBI Official Full Name

ephrin-A1

NCBI Official Synonym Full Names

ephrin A1

NCBI Official Symbol

Efna1

NCBI Official Synonym Symbols

B61

UniProt Protein Name

Ephrin-A1

UniProt Synonym Protein Names

EPH-related receptor tyrosine kinase ligand 1; LERK-1

Protein Family

Ephrin

UniProt Gene Name

Efna1

UniProt Synonym Gene Names

Epgl1; Lerk1; LERK-1

UniProt Entry Name

EFNA1_RAT

NCBI Protein Information

ephrin-A1

NCBI Summary for Efna1

ligand of receptor tyrosine kinases; involved in thymic function and development [RGD, Feb 2006]

UniProt Comments for Efna1

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis ().

Research Articles on Efna1

1. The findings that ephrinA1-PE38/GM-CSF had a high efficacy in the activation of the dendritic cells would facilitate the development of in vivo dendritic-cell vaccines for the treatment of gliomas in rats

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Efna1 recombinant protein

Reference Product	PubMed Publications
Epha2 recombinant protein	>18 publications with Efna1 and Epha2
Epha1 recombinant protein	>5 publications with Efna1 and Epha1
Epha3 recombinant protein	>3 publications with Efna1 and Epha3
Epha8 recombinant protein	>2 publications with Efna1 and Epha8
Epha10 recombinant protein	>1 publications with Efna1 and Epha10
Epha4 recombinant protein	>1 publications with Efna1 and Epha4

Pathways associated with Efna1 recombinant protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
EPH-Ephrin Signaling Pathway antibodies	EPH-Ephrin Signaling Pathway Diagram
EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies	EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
EPHA-mediated Growth Cone Collapse Pathway antibodies	EPHA-mediated Growth Cone Collapse Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
Rap1 Signaling Pathway antibodies	Rap1 Signaling Pathway Diagram

Diseases associated with Efna1 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>13 publications with Efna1 and Carcinoma
Neoplasm Metastasis Antibodies	>4 publications with Efna1 and Neoplasm Metastasis
Lung Neoplasms Antibodies	>3 publications with Efna1 and Lung Neoplasms
Liver Neoplasms Antibodies	>3 publications with Efna1 and Liver Neoplasms
Liver Diseases Antibodies	>3 publications with Efna1 and Liver Diseases
Cell Transformation, Neoplastic Antibodies	>2 publications with Efna1 and Cell Transformation, Neoplastic
Carcinoma, Hepatocellular Antibodies	>2 publications with Efna1 and Carcinoma, Hepatocellular
Inflammation Antibodies	>2 publications with Efna1 and Inflammation
Brain Diseases Antibodies	>2 publications with Efna1 and Brain Diseases
Necrosis Antibodies	>2 publications with Efna1 and Necrosis

Organs/Tissues associated with Efna1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>6 publications with Efna1 and Liver
Lung Antibodies	>5 publications with Efna1 and Lung
Brain Antibodies	>4 publications with Efna1 and Brain
Embryonic Tissue Antibodies	>2 publications with Efna1 and Embryonic Tissue
Heart Antibodies	>1 publications with Efna1 and Heart
Muscle Antibodies	>1 publications with Efna1 and Muscle
Eye Antibodies	>1 publications with Efna1 and Eye
Kidney Antibodies	>1 publications with Efna1 and Kidney
Connective Tissue Antibodies	>1 publications with Efna1 and Connective Tissue