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Inter-Alpha-Trypsin Inhibitor Heavy Chain H1 (ITIH1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS958289

This protein is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this… More details

$1450 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1), Recombinant Protein
Full Product Name
Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)
Product Gene Name
Sequence
SKSSEKRQAV DTAVDGVFIR SLKVNCKVTS RFAHYVVTSQ VVNTANEARE VAFDLEIPKT AFISDFAVTA DGNAFIGDIK DKVTAWKQYR KAAISGENAG LVRASGRTME QFTIHLTVNP QSKVTFQLTY EEVLKRNHMQ YEIVIKVKPK QLVHHFEIDV DIFEPQGISK LDAQASFLPK ELAAQTIKKS FSGKKGHVLF RPTVSQQQSC PTCSTSLLNG HFKVTYDVSR DKICDLLVAN NHFAHFFAPQ NLTNMNKNVV FVIDISGSMR GQKVKQTKEA LLKILGDMQP GDYFDLVLFG TRVQSWKGSL VQASEANLQA AQDFVRGFSL DEATNLNGGL LRGIEILNQV QESLPELSNH ASILIMLTDG DPTEGVTDRS QILKNVRNAI RGRFPLYNLG FGHNVDFNFL EVMSMENNGR AQRIYEDHDA TQQLQGFYSQ VAKPLLVDVD LQYPQDAVLA LTQNHHKQYY EGSEIVVAGR IADNKQSSFK ADVQAHGEGQ EFSITCLVDE EEMKKLLRER GHMLENHVER LWAYLTIQEL LAKRMKVDRE ERANLSSQAL QMSLDYGFVT PLTSMSIRGM ADQDGLKPTI DKPSEDSPPL EMLGPRRTFV LSALQPSPTH SSSNTQRLPD RVTGVDTD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
69,495 Da
Sequence Positions
35-672, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
147270
3D Structure
ModBase 3D Structure for P19827
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ITIH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITIH1 purchase

MBS958289 is a recombinant protein targeting ITIH1. Also known as Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ITIH1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
inter-alpha-trypsin inhibitor heavy chain H1 isoform b
NCBI Official Synonym Full Names
inter-alpha-trypsin inhibitor heavy chain 1
NCBI Official Symbol
ITIH1
NCBI Official Synonym Symbols
H1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1
UniProt Protein Name
Inter-alpha-trypsin inhibitor heavy chain H1
UniProt Synonym Protein Names
Inter-alpha-trypsin inhibitor complex component III; Serum-derived hyaluronan-associated protein; SHAP
UniProt Gene Name
ITIH1
UniProt Synonym Gene Names
IGHEP1; ITI heavy chain H1; ITI-HC1; Inter-alpha-inhibitor heavy chain 1; SHAP
NCBI Protein Information
inter-alpha-trypsin inhibitor heavy chain H1

NCBI Summary for ITIH1

This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]
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UniProt Comments for ITIH1

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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