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Connective Tissue Growth Factor (CTGF) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS958904

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts,… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Connective tissue growth factor (Ctgf), Recombinant Protein
Full Product Name
Recombinant Mouse Connective tissue growth factor (Ctgf), partial
Product Gene Name
Ctgf recombinant protein
Product Synonym Names
CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Protein FISP-12
Sequence
QDCSAQCQCA AEAAPHCPAG VSLVLDGCGC CRVCAKQLGE LCTERDPCDP HKGLFCDFGS PANRKIGVCT AKDGAPCVFG GSVYRSGESF QSSCKYQCTC LDGAVGCVPL CSMDVRLPSP DCPFPRRVKL PGKCCEEWVC DEPKDRTAVG PALAAYRLED TFGPDPTMMR ANCLVQTTEW SACSKTCGMG ISTRVTNDNT FCRLEKQSRL CMVRPCEADL EENIKKGKKC IRTPKIAKPV KFELSGCTSV KTYRAKFCGV CTDGRCCTPH RTTTLPVEFK CPDGEIMKKN MMFIKTCACH YNCPGDNDIF ESLYYRKMY
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
53.5 kDa
Sequence Positions
26-344aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P29268
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Ctgf recombinant protein

Mouse CTGF Recombinant Protein – Cat# MBS958904

Product References and Citations for Ctgf recombinant protein

Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein.Ryseck R.-P., Macdonald-Bravo H., Mattei M.-G., Bravo R.Cell Growth Differ. 2:225-233(1991) Identification of a gene family regulated by transforming growth factor-beta.Brunner A., Chinn J., Neubauer M.G., Purchio A.F.DNA Cell Biol. 10:293-300(1991) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Cyr61 and Fisp12 are both ECM-associated signaling molecules activities, metabolism, and localization during development.Kireeva M.L., Latinkic B.V., Kolesnikova T.V., Chen C.-C., Yang G.P., Abler A.S., Lau L.F.Exp. Cell Res. 233:63-77(1997) Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo.Babic A.M., Chen C.-C., Lau L.F.Mol. Cell. Biol. 19:2958-2966(1999)

Other Notes

Small volumes of Ctgf recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ctgf purchase

MBS958904 is a recombinant protein targeting Ctgf. Also known as Recombinant Mouse Connective tissue growth factor (Ctgf), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Ctgf. It may not necessarily be applicable to this product.

NCBI GI #
171846283
NCBI GeneID
14219
NCBI Accession #
NP_034347.2
UniProt Primary Accession #
P29268
UniProt Secondary Accession #
Q922U0; G5E830
UniProt Related Accession #
P29268
GenBank Nucleotide #
NM_010217.2
NCBI Official Full Name
connective tissue growth factor
NCBI Official Synonym Full Names
connective tissue growth factor
NCBI Official Symbol
Ctgf
NCBI Official Synonym Symbols
Ccn2; Hcs24; Fisp12; fisp-12
UniProt Protein Name
Connective tissue growth factor
UniProt Synonym Protein Names
CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Protein FISP-12
Protein Family
Connective tissue growth factor
UniProt Gene Name
Ctgf
UniProt Synonym Gene Names
Ccn2; Fisp-12; Fisp12; Hcs24
UniProt Entry Name
CTGF_MOUSE
NCBI Protein Information
connective tissue growth factor

UniProt Comments for Ctgf

CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cell adhesion

Cellular Component: cell cortex; cis-Golgi network; cytosol; extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; perinuclear region of cytoplasm; proteinaceous extracellular matrix

Molecular Function: fibronectin binding; growth factor activity; heparin binding; insulin-like growth factor binding; integrin binding; protein C-terminus binding

Biological Process: angiogenesis; cartilage condensation; cell adhesion; cell differentiation; cell migration; cell-cell signaling; cell-matrix adhesion; fibroblast growth factor receptor signaling pathway; integrin-mediated signaling pathway; lung development; ossification; positive regulation of caspase activity; positive regulation of cell activation; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; regulation of cell growth; regulation of chondrocyte differentiation; tissue homeostasis
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Research Articles on Ctgf

1. findings suggest CCN2 as a candidate of the fourth factor in the RANK/RANKL/OPG system for osteoclastogenesis, which regulates OPG and RANK via direct interaction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Ctgf recombinant protein

 Reference Product  PubMed Publications
 Tgfb1 recombinant protein  >727 publications with Ctgf and Tgfb1
 Yap1 recombinant protein  >22 publications with Ctgf and Yap1
 Wwtr1 recombinant protein  >13 publications with Ctgf and Wwtr1
 Tead4 recombinant protein  >5 publications with Ctgf and Tead4
 Tead1 recombinant protein  >3 publications with Ctgf and Tead1

Pathways associated with Ctgf recombinant protein

 Products by Pathway  Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 PodNet: Protein-protein Interactions In The Podocyte Pathway antibodies  PodNet: Protein-protein Interactions In The Podocyte Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with Ctgf recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1381 publications with Ctgf and Fibrosis
 Kidney Diseases Antibodies  >380 publications with Ctgf and Kidney Diseases
 Inflammation Antibodies  >332 publications with Ctgf and Inflammation
 Cardiovascular Diseases Antibodies  >325 publications with Ctgf and Cardiovascular Diseases
 Lung Diseases Antibodies  >211 publications with Ctgf and Lung Diseases
 Heart Diseases Antibodies  >202 publications with Ctgf and Heart Diseases
 Liver Diseases Antibodies  >200 publications with Ctgf and Liver Diseases
 Hypertension Antibodies  >173 publications with Ctgf and Hypertension
 Necrosis Antibodies  >160 publications with Ctgf and Necrosis
 Pulmonary Fibrosis Antibodies  >159 publications with Ctgf and Pulmonary Fibrosis

Organs/Tissues associated with Ctgf recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >2795 publications with Ctgf and Connective Tissue
 Kidney Antibodies  >633 publications with Ctgf and Kidney
 Other Antibodies  >416 publications with Ctgf and Other
 Lung Antibodies  >322 publications with Ctgf and Lung
 Liver Antibodies  >317 publications with Ctgf and Liver
 Heart Antibodies  >314 publications with Ctgf and Heart
 Bone Antibodies  >312 publications with Ctgf and Bone
 Skin Antibodies  >240 publications with Ctgf and Skin
 Embryonic Tissue Antibodies  >191 publications with Ctgf and Embryonic Tissue
 Eye Antibodies  >172 publications with Ctgf and Eye
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