Mouse NR2F6 Recombinant Protein – Cat# MBS958949

Nuclear Receptor Subfamily 2 Group F Member 6 (NR2F6) Mouse Recombinant Protein

Name: NR2F6 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS958949
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS958949

MBS958949 is a recombinant protein targeting Nr2f6. Also known as Recombinant Mouse Nuclear receptor subfamily 2 group F member 6 (Nr2f6). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$440 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nuclear receptor subfamily 2 group F member 6 (Nr2f6), Recombinant Protein

Full Product Name

Recombinant Mouse Nuclear receptor subfamily 2 group F member 6 (Nr2f6)

Product Gene Name

Nr2f6 recombinant protein

Sequence

MAMVTGGWGD PGGDTNGVDK AGGSYPRATE DDSASPPGAT SDAEPGDEER PGLQVDCVVC GDKSSGKHYG VFTCEGCKSF FKRSIRRNLS YTCRSNRDCQ IDQHHRNQCQ YCRLKKCFRV GMRKEAVQRG RIPHALPGPA ACSPPGATGV EPFTGPPVSE LIAQLLRAEP YPAAGRFGGG GAVLGIDNVC ELAARLLFST VEWARHAPFF PELPAADQVA LLRLSWSELF VLNAAQAALP LHTAPLLAAA GLHAAPMAAE RAVAFMDQVR AFQEQVDKLG RLQVDAAEYG CLKAIALFTP DACGLSDPAH VESLQEKAQV ALTEYVRAQY PSQPQRFGRL LLRLPALRAV PASLISQLFF MRLVGKTPIE TLIRDMLLSG STFNWPYGSG

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

49.4 kDa

Sequence Positions

1-390aa, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P43136

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nr2f6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Nr2f6. It may not necessarily be applicable to this product.

NCBI GI #

112807199

NCBI GeneID

13864

NCBI Accession #

NP_034280.2

UniProt Primary Accession #

P43136

UniProt Secondary Accession #

Q61504; Q922G8

UniProt Related Accession #

P43136

GenBank Nucleotide #

NM_010150.2

NCBI Official Full Name

nuclear receptor subfamily 2 group F member 6

NCBI Official Synonym Full Names

nuclear receptor subfamily 2, group F, member 6

NCBI Official Symbol

Nr2f6

NCBI Official Synonym Symbols

EAR2; Erbal2; AV090102; COUP-TF3

UniProt Protein Name

Nuclear receptor subfamily 2 group F member 6

UniProt Synonym Protein Names

COUP transcription factor 3; COUP-TF3; V-erbA-related protein 2; EAR-2

Protein Family

Nuclear receptor subfamily

UniProt Gene Name

Nr2f6

UniProt Synonym Gene Names

Ear-2; Ear2; Erbal2; COUP-TF3; EAR-2

NCBI Protein Information

nuclear receptor subfamily 2 group F member 6

UniProt Comments for Nr2f6

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Research Articles on Nr2f6

1. NR2F6 is a central checkpoint for cancer immune surveillance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Nr2f6 recombinant protein

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram
PluriNetWork Pathway antibodies	PluriNetWork Pathway Diagram

Diseases associated with Nr2f6 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with Nr2f6 and Neoplasms
Hypertension Antibodies	>2 publications with Nr2f6 and Hypertension
Carcinoma Antibodies	>2 publications with Nr2f6 and Carcinoma
Leukemia Antibodies	>1 publications with Nr2f6 and Leukemia
Vascular Diseases Antibodies	>1 publications with Nr2f6 and Vascular Diseases
Cardiovascular Diseases Antibodies	>1 publications with Nr2f6 and Cardiovascular Diseases
Inflammation Antibodies	>1 publications with Nr2f6 and Inflammation
Drug Toxicity Antibodies	>1 publications with Nr2f6 and Drug Toxicity
Breast Neoplasms Antibodies	>1 publications with Nr2f6 and Breast Neoplasms

Organs/Tissues associated with Nr2f6 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>5 publications with Nr2f6 and Brain
Liver Antibodies	>3 publications with Nr2f6 and Liver
Thyroid Antibodies	>3 publications with Nr2f6 and Thyroid
Inner Ear Antibodies	>1 publications with Nr2f6 and Inner Ear
Heart Antibodies	>1 publications with Nr2f6 and Heart
Intestine Antibodies	>1 publications with Nr2f6 and Intestine