Cadherin-1 (CDH1) Mouse Recombinant Protein

CDH1: a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis. Has a potent invasive suppressor role.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion; Ubiquitin ligase

Cellular Component: apical junction complex; Golgi apparatus; internal side of plasma membrane; focal adhesion; cell surface; lateral loop; basolateral plasma membrane; integral to membrane; intercellular junction; catenin complex; trans-Golgi network; actin cytoskeleton; adherens junction; cell-cell adherens junction; membrane; apical part of cell; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; nerve terminal; cell junction; endosome; lateral plasma membrane

Molecular Function: protein domain specific binding; protein binding; metal ion binding; gamma-catenin binding; beta-catenin binding; GTPase activating protein binding; ankyrin binding; cell adhesion molecule binding; calcium ion binding; glycoprotein binding; protein phosphatase binding

Biological Process: in utero embryonic development; positive regulation of transcription, DNA-dependent; regulation of caspase activity; regulation of epithelial cell proliferation; trophectodermal cell differentiation; regulation of water loss via skin; cell-cell adhesion; regulation of protein localization; sensory perception of sound; synaptogenesis; protein metabolic process; calcium-dependent cell-cell adhesion; positive regulation of transcription factor import into nucleus; negative regulation of cell-cell adhesion; homophilic cell adhesion; cell adhesion; protein homooligomerization; negative regulation of epithelial cell proliferation