BDNF/Nt-3 Growth Factors Receptor (NTRK2) Mouse Recombinant Protein

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family

Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; cell; dendrite; postsynaptic density; dendritic spine; integral to membrane; excitatory synapse; terminal button; perikaryon; cytosol; postsynaptic membrane; growth cone; membrane; cell soma; axon; cytoplasm; plasma membrane; presynaptic active zone; intracellular; nerve terminal; endosome; receptor complex

Molecular Function: neurotrophin binding; protein homodimerization activity; ephrin receptor binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; protein kinase activity; brain-derived neurotrophic factor receptor activity; transferase activity; protein binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding

Biological Process: mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; multicellular organismal development; protein amino acid autophosphorylation; regulation of neurotransmitter secretion; neuron migration; regulation of dendrite development; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; regulation of metabolic process; negative regulation of neuron apoptosis; vasculogenesis; cell differentiation; neuromuscular junction development; central nervous system neuron development; nervous system development; regulation of GTPase activity; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system neuron development; positive regulation of phosphoinositide 3-kinase cascade; glutamate secretion; long-term memory; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway