Sulfotransferase 1a1 (SULT1A1) Mouse Recombinant Protein

SULT1A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.8.2.1; Transferase; Energy Metabolism - sulfur

Cellular Component: cytoplasm; cytosol

Molecular Function: phenanthrol sulfotransferase activity; protein homodimerization activity; trans-3,4-dihydrodiolphenanthrene sulfotransferase activity; proteoglycan sulfotransferase activity; 3'-phosphoadenosine 5'-phosphosulfate binding; 2-phenanthrol sulfotransferase activity; nucleotide binding; galactose 3-O-sulfotransferase activity; tyrosine-ester sulfotransferase activity; aryl sulfotransferase activity; 1-phenanthrol sulfotransferase activity; transferase activity; 3-phenanthrol sulfotransferase activity; sulfotransferase activity; HNK-1 sulfotransferase activity; N-acetylglucosamine 6-O-sulfotransferase activity; 4-phenanthrol sulfotransferase activity; trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity; heparan sulfate 2-O-sulfotransferase activity; cholesterol sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activity; 9-phenanthrol sulfotransferase activity; heparan sulfate 6-O-sulfotransferase activity

Biological Process: steroid metabolic process; estrogen metabolic process; xenobiotic metabolic process; sulfation; 4-nitrophenol metabolic process; response to glucocorticoid stimulus; catecholamine metabolic process; lipid metabolic process; drug metabolic process