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Thymidine Kinase (TK1) Human Herpesvirus 1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS959745

MBS959745 is a recombinant protein targeting TK1. Also known as Recombinant Human herpesvirus 1 Thymidine kinase. Host: E.coli. More details

$605 / 0.2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Thymidine kinase (TK1), Recombinant Protein
Full Product Name
Recombinant Human herpesvirus 1 Thymidine kinase
Product Gene Name
TK1 recombinant protein
Sequence
MASYPCHQHA SAFDQAARSR GHNNRRTALR PRRQQEATEV RPEQKMPTLL RVYIDGPHGM GKTTTTQLLV ALGSRDDIVY VPEPMTYWRV LGASETIANI YTTQHRLDQG EISAGDAAVV MTSAQITMGM PYAVTDAVLA PHIGGEAGSS HAPPPALTLI FDRHPIAALL CYPAARYLMG SMTPQAVLAF VALIPPTLPG TNIVLGALPE DRHIDRLAKR QRPGERLDLA MLAAIRRVYG LLANTVRYLQ CGGSWREDWG QLSGTAVPPQ GAEPQSNAGP RPHIGDTLFT LFRAPELLAP NGDLYNVFAW ALDVLAKRLR SMHVFILDYD QSPAGCRDAL LQLTSGMVQT HVTTPGSIPT ICDLARTFAR EMGEAN
Host
E.coli
Form/Format
Liquid, dissolved in 20mM Tris-HCl, 500mM NaCl, pH 8.0, 50% glycerol
Purity/Purification
85% ± 5% by SDS-PAGE
Preparation and Storage
Store: Aliquot and store at < or = 20 degree C. Avoid repeated freeze/thaw cycles; -20 degree C for one year.
Molecular Weight
41.32kD
Sequence Positions
1-376
OMIM
188300
3D Structure
ModBase 3D Structure for P04183
Tag
his-tag
Product Note
Applications are user defined. Product is developed and quality control tested in house, data or additional information may be provided upon request. The researcher needs to establish and confirm the suitability of the product for their application.

Product Categories/Family for TK1 recombinant protein

Epigenetics and Nuclear Signaling; Raw Materials Assay Development
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for TK1 recombinant protein
Calibrator/Standard

SDS-Page of TK1 recombinant protein

Human Herpesvirus 1 TK1 Recombinant Protein – Cat# MBS959745

Product References and Citations for TK1 recombinant protein

Human thymidine kinase gene molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.Bradshaw H.D. Jr., Deininger P.L.Mol. Cell. Biol. 4:2316-2320(1984)

Other Notes

Small volumes of TK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TK1. It may not necessarily be applicable to this product.

NCBI GI #
164698438
NCBI GeneID
7083
NCBI Accession #
NP_003249.3
UniProt Primary Accession #
P04183
UniProt Secondary Accession #
Q969V0; Q9UMG9; B2RC58
UniProt Related Accession #
P04183
GenBank Nucleotide #
NM_003258.4
NCBI Official Full Name
thymidine kinase, cytosolic
NCBI Official Synonym Full Names
thymidine kinase 1, soluble
NCBI Official Symbol
TK1
NCBI Official Synonym Symbols
TK2
UniProt Protein Name
Thymidine kinase, cytosolic
Protein Family
Thymidine kinase
UniProt Gene Name
TK1
UniProt Entry Name
KITH_HUMAN
NCBI Protein Information
thymidine kinase, cytosolic

UniProt Comments for TK1

TK: cytosolic thymidine kinase. Phosphorylated during mitosis. Its enzymatic activity is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

Protein type: EC 2.7.1.21; Xenobiotic Metabolism - drug metabolism - other enzymes; Kinase, other; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 17q23.2-q25.3

Cellular Component: cytosol

Molecular Function: ATP binding; identical protein binding; nucleoside kinase activity; protein binding; thymidine kinase activity; zinc ion binding

Biological Process: deoxyribonucleoside monophosphate biosynthetic process; fetal process involved in parturition; gut development; liver development; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleotide biosynthetic process; phosphorylation; protein homotetramerization; pyrimidine base metabolic process; pyrimidine nucleoside salvage; response to copper ion; response to cortisol stimulus; response to nutrient levels; response to toxin; skeletal muscle cell proliferation; thymidine metabolic process
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Research Articles on TK1

1. Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TK1 recombinant protein

 Reference Product  PubMed Publications
 TYMS recombinant protein  >5 publications with TK1 and TYMS
 CDA recombinant protein  >4 publications with TK1 and CDA
 DCTD recombinant protein  >2 publications with TK1 and DCTD
 CDK1 recombinant protein  >2 publications with TK1 and CDK1
 TYMP recombinant protein  >2 publications with TK1 and TYMP
 DUT recombinant protein  >1 publications with TK1 and DUT

Pathways associated with TK1 recombinant protein

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with TK1 recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >57 publications with TK1 and Carcinoma
 Breast Neoplasms Antibodies  >33 publications with TK1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >27 publications with TK1 and Lung Neoplasms
 Lung Diseases Antibodies  >23 publications with TK1 and Lung Diseases
 Adenocarcinoma Antibodies  >22 publications with TK1 and Adenocarcinoma
 Colorectal Neoplasms Antibodies  >17 publications with TK1 and Colorectal Neoplasms
 Disease Models, Animal Antibodies  >16 publications with TK1 and Disease Models, Animal
 Liver Neoplasms Antibodies  >9 publications with TK1 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >9 publications with TK1 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >9 publications with TK1 and Nervous System Diseases

Organs/Tissues associated with TK1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >107 publications with TK1 and Blood
 Lung Antibodies  >33 publications with TK1 and Lung
 Liver Antibodies  >21 publications with TK1 and Liver
 Brain Antibodies  >20 publications with TK1 and Brain
 Lymph Antibodies  >17 publications with TK1 and Lymph
 Lymph Node Antibodies  >17 publications with TK1 and Lymph Node
 Bone Antibodies  >13 publications with TK1 and Bone
 Muscle Antibodies  >12 publications with TK1 and Muscle
 Prostate Antibodies  >9 publications with TK1 and Prostate
 Bone Marrow Antibodies  >8 publications with TK1 and Bone Marrow
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