Human MMP10 Recombinant Protein – Cat# MBS959840

Stromelysin-2 (MMP10) Human Recombinant Protein

Name: MMP10 Recombinant Protein; Stromelysin-2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS959840
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS959840

Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. More details

$385 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Stromelysin-2 (MMP10), Recombinant Protein

Full Product Name

Recombinant Human Stromelysin-2 (MMP10)

Product Gene Name

MMP10 recombinant protein

Product Synonym Gene Name

MMP10; STMY2

Product Synonym Names

Stromelysin-2; SL-2; EC=3.4.24.22; Matrix metalloproteinase-10; MMP-10; Transin-2

Sequence

FSSFPGMPKW RKTHLTYRIV NYTPDLPRDA VDSAIEKALK VWEEVTPLTF SRLYEGEADI MISFAVKEHG DFYSFDGPGH SLAHAYPPGP GLYGDIHFDD DEKWTEDASG TNLFLVAAHE LGHSLGLFHS ANTEALMYPL YNSFTELAQF RLSQDDVNGI QSLYGPPPAS TEEPLVPTKS VPSGSEMPAK CDPALSFDAI STLRGEYLFF KDRYFWRRSH WNPEPEFHLI SAFWPSLPSY LDAAYEVNSR DTVFIFKGNE FWAIRGNEVQ AGYPRGIHTL GFPPTIRKID AAVSDKEKKK TYFFAADKYW RFDENSQSME QGFPRLIADD FPGVEPKVDA VLQAFGFFYF FSGSSQFEFD PNARMVTHIL KSNSWLHC

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

45 kDa

Sequence Positions

99-476. Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

185260

3D Structure

ModBase 3D Structure for P09238

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for MMP10 recombinant protein

Cancer

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MMP10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP10 purchase

MBS959840 is a recombinant protein targeting MMP10. Also known as Recombinant Human Stromelysin-2 (MMP10). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP10. It may not necessarily be applicable to this product.

NCBI GI #

4505205

NCBI GeneID

4319

NCBI Accession #

NP_002416.1

UniProt Primary Accession #

P09238

UniProt Secondary Accession #

Q53HH9; B2R9X9

UniProt Related Accession #

P09238

GenBank Nucleotide #

NM_002425.2

NCBI Official Full Name

stromelysin-2 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 10 (stromelysin 2)

NCBI Official Symbol

MMP10

NCBI Official Synonym Symbols

SL-2; STMY2

UniProt Protein Name

Stromelysin-2

UniProt Synonym Protein Names

Matrix metalloproteinase-10; MMP-10; Transin-2

Protein Family

Stromelysin

UniProt Gene Name

MMP10

UniProt Synonym Gene Names

STMY2; SL-2; MMP-10

UniProt Entry Name

MMP10_HUMAN

NCBI Protein Information

stromelysin-2; MMP-10; transin 2; transin-2; stromelysin 2; matrix metalloprotease 10; matrix metalloproteinase-10; matrix metalloproteinase 10 (stromelysin 2)

NCBI Summary for MMP10

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP10

MMP10: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. Belongs to the peptidase M10A family.

Protein type: Secreted; EC 3.4.24.22; Protease; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis; regulation of cell migration

Research Articles on MMP10

1. MMP-10 is involved in the development of microvascular complications in type 1 diabetes and emerges as a potential therapeutic target for slowing down the evolution of diabetic nephropathy and retinopathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP10 recombinant protein

Reference Product	PubMed Publications
MMP9 recombinant protein	>26 publications with MMP10 and MMP9

Pathways associated with MMP10 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram

Diseases associated with MMP10 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>34 publications with MMP10 and Neoplasms
Inflammation Antibodies	>18 publications with MMP10 and Inflammation
Cardiovascular Diseases Antibodies	>11 publications with MMP10 and Cardiovascular Diseases
Adenocarcinoma Antibodies	>10 publications with MMP10 and Adenocarcinoma
Lung Diseases Antibodies	>9 publications with MMP10 and Lung Diseases
Neoplasm Metastasis Antibodies	>9 publications with MMP10 and Neoplasm Metastasis
Necrosis Antibodies	>7 publications with MMP10 and Necrosis
Heart Diseases Antibodies	>5 publications with MMP10 and Heart Diseases
Lung Neoplasms Antibodies	>5 publications with MMP10 and Lung Neoplasms
Breast Neoplasms Antibodies	>4 publications with MMP10 and Breast Neoplasms

Organs/Tissues associated with MMP10 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>26 publications with MMP10 and Vascular
Lung Antibodies	>13 publications with MMP10 and Lung
Muscle Antibodies	>12 publications with MMP10 and Muscle
Uterus Antibodies	>6 publications with MMP10 and Uterus
Brain Antibodies	>5 publications with MMP10 and Brain
Skin Antibodies	>4 publications with MMP10 and Skin
Mouth Antibodies	>4 publications with MMP10 and Mouth
Liver Antibodies	>4 publications with MMP10 and Liver
Intestine Antibodies	>3 publications with MMP10 and Intestine
Ovary Antibodies	>3 publications with MMP10 and Ovary